4-(4-三氟甲基苯基)吡啶合成路线 （共 8 条）
反应条件
potassium phosphate; tris-(dibenzylideneacetone)dipalladium(0); tri-cyclo-hexyl-phosphine in 1,4-dioxane T=100°C; Inert atmosphereSealed tube;
参考文献
BIOENERGENIX; MCCALL, John, M.; MCKEARN, John; ROMERO, Donnal, L.; CLAIR, Michael
Patent: WO2011/28947 A2, 2011 ;
Location in patent: Page/Page column 61 ;
WO 2011/028947 A1
反应条件
tetra-butylammonium acetate; Pd EnCat-30TM in ethanol T=120°C; Suzuki cross-coupling; 0.166667 h; microwave irradiation;
参考文献
Baxendale, Ian R.; Griffiths-Jones, Charlotte M.; Ley, Steven V.; Tranmer, Geoffrey K.
Chemistry - A European Journal, 2006 , vol. 12, # 16 p. 4407 - 4416
反应条件
sodium carbonate in water; ethyl acetate
参考文献
Bo, Yunxin Y.; Chakrabarti, Partha P.; Chen, Ning; Doherty, Elizabeth M.; Fotsch, Christopher H.; Han, Nianhe; Kelly, Michael G.; Liu, Qingyian; Norman, Mark Henry; Ognyanov, Vassil I.; Wang, Xianghong; Zhu, Jiawang
Patent: US2003/195201 A1, 2003 ;
US 20030195201 A1
反应条件
water; potassium carbonate; tetrakis(triphenylphosphine) palladium(0) in ethylene glycol dimethyl ether 18 h; Heating;
参考文献
Lohse, Olivier; Thevenin, Philippe; Waldvogel, Erwin
Synlett, 1999 , # 1 p. 45 - 48
反应条件
1.1: ZnCl2; CoCl2; Bu4NBF4 / acetonitrile; dimethylformamide / Electrochemical reaction 1.2: CuCN; LiCl / 2 h / 0 - 20 °C 2.1: 30 percent H2O2 / dimethylformamide / 12 h / 20 °C View Scheme
参考文献
BIOENERGENIX; MCCALL, John, M.; MCKEARN, John; ROMERO, Donnal, L.; CLAIR, Michael
Patent: WO2011/28947 A2, 2011 ;
WO 2011/028947 A1
反应条件
1.1: ZnCl2; CoCl2; Bu4NBF4 / acetonitrile; dimethylformamide / Electrochemical reaction 1.2: CuCN; LiCl / 2 h / 0 - 20 °C 2.1: 30 percent H2O2 / dimethylformamide / 12 h / 20 °C View Scheme
参考文献
Gall, Erwan Le; Gosmini, Corinne; Nedelec, Jean-Yves; Perichon, Jacques
Tetrahedron, 2001 , vol. 57, # 10 p. 1923 - 1927
反应条件
Br(1-)*C18H28N3(1+); sodium t-butanolate T=110°C; 48 h; Inert atmosphere;
参考文献
Chen, Wen-Ching; Hsu, Yu-Chen; Shih, Wei-Chun; Lee, Ching-Yu; Chuang, Wen-Han; Tsai, Yi-Fang; Chen, Peter Ping-Yu; Ong, Tiow-Gan
Chemical Communications, 2012 , vol. 48, # 53 p. 6702 - 6704
反应条件
1: With hydrogen; trifluoroacetic acid; 5 Pd(II)/C(eggshell) in methanol T=30°C; 2: With sodium hydroxide in water pH=8 - 9;
参考文献
BIOENERGENIX; MCCALL, John, M.; MCKEARN, John; ROMERO, Donnal, L.; CLAIR, Michael
Patent: WO2011/28947 A2, 2011 ;
Location in patent: Page/Page column 61-62 ;
WO 2011/028947 A1
