3,5-二氯-4-羟基苄醇合成路线 （共 12 条）
反应条件
2,3-dicyano-5,6-dichloro-p-benzoquinone in 1,4-dioxane 16 h; Ambient temperature;
参考文献
Becker, Hans-Dieter; Bjoerk, Anders; Adler, Erich
Journal of Organic Chemistry, 1980 , vol. 45, # 9 p. 1596 - 1600
反应条件
potassium fluoride; tetrabutyl-ammonium chloride 30 h; Heating;
参考文献
Archiv der Pharmazie, , vol. 316, # 3 p. 193 - 201
反应条件
borane-THF in tetrahydrofuran
T=0 - 20°C; 13.25 h;
参考文献
ACTELION PHARMACEUTICALS LTD
Patent: WO2006/21401 A2, 2006 ;
Location in patent: Page/Page column 31 ;
WO 2006/021401 A2
参考文献
Rosales, Carmen Almansa; Gonzalez Gonzalez, Concepcion; Torres Barreda, Maria Carmen
Patent: US2003/176481 A1, 2003 ;
反应条件
sodium hydroxide in water
T=70°C; 192 h;
参考文献
Renger
Archiv der Pharmazie, 1983 , vol. 316, # 3 p. 193 - 201
反应条件
sodium hydroxide in water
T=80°C; 24 h;
参考文献
Dimmel, Donald R.; Shepard, Donaline
Journal of Organic Chemistry, 1982 , vol. 47, # 1 p. 22 - 29
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
12 h; Heating;
参考文献
Beller; Eckert; Holla
Journal of Organic Chemistry, 1998 , vol. 63, # 16 p. 5658 - 5661
反应条件
1: 100 percent / HCl / diethyl ether
2: NaOH / H2O / 24 h / 80 °C
View Scheme
参考文献
Dimmel, Donald R.; Shepard, Donaline
Journal of Organic Chemistry, 1982 , vol. 47, # 1 p. 22 - 29
反应条件
sodium hydroxide; sodium tetrahydroborate
参考文献
Claus,P. et al.
Monatshefte fuer Chemie, 1972 , vol. 103, p. 1178 - 1193
参考文献
Yamasaki
Kogyo Kagaku Zasshi, 1955 , vol. 58, p. 972
Chem.Abstr., 1956 , p. 12927
