1: 63 percent / K2CO3 / dimethylformamide / 48 h / 80 °C 2: 94 percent / aq. HCl / tetrahydrofuran / 3 h / Ambient temperature 3: 85 percent / pyridine / 24 h / 0 °C 4: 99 percent / K2CO3 / dimethylformamide; H2O / 24 h / Ambient temperature 5: 73 percent / Ti(O-i-Pr)4, KHMDS / tetrahydrofuran; toluene / 2 h / -70 °C 6: 95 percent / H2 / Pd/C / methanol / 3 h / 760 Torr / Ambient temperature 7: 100 percent / Na-Hg, Na2HPO4 / methanol / 2 h / 0 °C 8: 85 percent / DMAP / pyridine / 1.) 0 deg C, 30 min, 2.) room temp., 24 h 9: 87 percent / NaBH4 / dimethylsulfoxide / 16 h / 45 °C 10: 92 percent / H2 / Pd/C / methanol / 18 h / 760 Torr / Ambient temperature 11: aq. NaHCO3, NaOCl, KBr, TEMPO / acetone / 2 h / 0 °C View Scheme

1: 63 percent / K2CO3 / dimethylformamide / 48 h / 80 °C 2: 94 percent / aq. HCl / tetrahydrofuran / 3 h / Ambient temperature 3: 85 percent / pyridine / 24 h / 0 °C 4: 99 percent / K2CO3 / dimethylformamide; H2O / 24 h / Ambient temperature 5: 73 percent / Ti(O-i-Pr)4, KHMDS / tetrahydrofuran; toluene / 2 h / -70 °C 6: 89 percent / H2 / Pd/C / methanol / 3102.9 Torr / Ambient temperature 7: 96 percent / Na-Hg, Na2HPO4 / methanol / 2 h / 0 °C View Scheme

1: 63 percent / K2CO3 / dimethylformamide / 48 h / 80 °C 2: 94 percent / aq. HCl / tetrahydrofuran / 3 h / Ambient temperature 3: 85 percent / pyridine / 24 h / 0 °C 4: 99 percent / K2CO3 / dimethylformamide; H2O / 24 h / Ambient temperature 5: 73 percent / Ti(O-i-Pr)4, KHMDS / tetrahydrofuran; toluene / 2 h / -70 °C 6: 89 percent / H2 / Pd/C / methanol / 3102.9 Torr / Ambient temperature 7: 96 percent / Na-Hg, Na2HPO4 / methanol / 2 h / 0 °C 8: aq, NaHCO3, KBr, TEMPO, NaOCl / acetone / 2 h / 0 °C 9: diethyl ether 10: 100 percent / CF3COOH / CH2Cl2 / 1 h / Ambient temperature 11: 1.) aq. HCl, 2.) propylene oxide / 1.) 100 deg C, 3 h, 2.) EtOH, heating View Scheme