1-苯基-1-环己基甲腈合成路线 （共 19 条）
反应条件
1: diisobutylaluminium hydride / |Inert atmosphere; |Schlenk technique 2: iron tribromide / toluene / 14 h / 80 °C / |Sealed tube; |Schlenk technique; |Inert atmosphere View Scheme
参考文献
Gutierrez-Bonet, Alvaro; Flores-Gaspar, Areli; Martin, Ruben
Journal of the American Chemical Society, 2013 , vol. 135, # 34 p. 12576 - 12579
反应条件
potassium hydroxide in diethylene glycol Heating;
参考文献
Kalir,A.; Pelah,K.
Israel Journal of Chemistry, 1967 , vol. 5, p. 223 - 229
反应条件
1: 72 percent / 48percent aq. HBr / 96 h / Heating 2: SOCl2 / 2 h / Heating View Scheme
参考文献
Kalir,A.; Pelah,K.
Israel Journal of Chemistry, 1967 , vol. 5, p. 223 - 229
反应条件
hydrogen bromide 96 h; Heating;
参考文献
The United States of America as represented by the Secretary of the Army
Patent: US5331010 A1, 1994 ;
反应条件
1: 72 percent / 48percent aq. HBr / 96 h / Heating 2: 89 percent / HCl / 2 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 34, # 11 p. 3159 - 3164
反应条件
lithium aluminium tetrahydride; diethyl ether
参考文献
Trivedi, Bharat K.; Holmes, Ann; Stoeber, Terri L.; Blankley, C. John; Roark, W. Howard; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 22 p. 3300 - 3307
反应条件
1: aq. KOH / ethane-1,2-diol / Heating
2: SOCl2 / Heating
3: (i) NaN3, toluene, (ii) aq. HCl, toluene
View Scheme
参考文献
Bonnekessel,J.; Ruechardt,C.
Chemische Berichte, 1973 , vol. 106, p. 2890 - 2903
反应条件
1: 72 percent / 48percent aq. HBr / 96 h / Heating
2: 89 percent / HCl / 2 h / Heating
3: 62 percent / LiAlH4 / tetrahydrofuran / 3 h / Heating
View Scheme
参考文献
Calderon; Newman; Tortella
Journal of Medicinal Chemistry, 1991 , vol. 34, # 11 p. 3159 - 3164
反应条件
1: 2-methyl tetrahydrofuran / 20 h / 15 °C / |Inert atmosphere
2: hydrogenchloride; water / 1 h / 60 °C / |Inert atmosphere
View Scheme
参考文献
Mateos, Carlos; Rincon, Juan A.; Villanueva, Jose
Tetrahedron Letters, 2013 , vol. 54, # 18 p. 2226 - 2230
