1-氨基-1-苯基环己烷合成路线 （共 22 条）
反应条件
1.1: magnesium / tetrahydrofuran / 1.17 h / Cooling with ice; Reflux
1.2: 3 h / 0 - 20 °C
2.1: sodium azide; trifluoroacetic acid / dichloromethane / 1.25 h / -5 - 0 °C / Inert atmosphere
3.1: lithium aluminium tetrahydride / diethyl ether / 3 h / 20 °C / Inert atmosphere
View Scheme
参考文献
Tagad, Harichandra D.; Hamada, Yoshio; Nguyen, Jeffrey-Tri; Hidaka, Koushi; Hamada, Takashi; Sohma, Youhei; Kimura, Tooru; Kiso, Yoshiaki
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 17 p. 5238 - 5246
反应条件
1: nitric acid / 100 - 110 °C / im geschlossenen Rohr
2: tin; hydrochloric acid
View Scheme
参考文献
Kurssanow
Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1906 , vol. 38, p. 1300
Chem. Zentralbl., 1907 , vol. 78, # I p. 1744
