6-氨基-1,4-苯并二氧杂环合成路线 （共 38 条）
反应条件
water T=20°C; Inert atmosphere; chemoselective reaction;
参考文献
Dey, Raju; Mukherjee, Nirmalya; Ahammed, Sabir; Ranu, Brindaban C.
Chemical Communications, 2012 , vol. 48, # 64 p. 7982 - 7984
反应条件
titanium(III) chloride; hydroxylammonium sulphate in water; acetic acid 0.5 h; Ambient temperature;
参考文献
Zorina, L. N.; Safiev, O. G.; Rakhmankulov, D. L.; Paushkin, Ya. M.
Doklady Chemistry, 1987 , vol. 296, # 10 p. 444 - 446
Dokl. Akad. Nauk SSSR Ser. Khim., 1987 , vol. 296, # 4 p. 887 - 890
反应条件
hydrogen; palladium on activated charcoal in methanol T=20°C; 24 h; Product distribution; Further Variations:ReagentsSolventsTemperaturesCatalystsreaction times;
参考文献
Mateu; Capilla; Harrak; Pujol
Tetrahedron, 2002 , vol. 58, # 26 p. 5241 - 5250
反应条件
bis (triortho-tolylphosphine)palladium(II) chloride; pyridine-3-carboxamide; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'- binaphthyl T=150°C; 16 h; Inert atmosphere;
参考文献
Romero; Harrak; Basset; Orue; Pujol
Tetrahedron, 2009 , vol. 65, # 10 p. 1951 - 1956
反应条件
1: sodium carbonate / glycerol / Heating 2: nitric acid / 60 °C 3: nickel; hydrazine / ethanol / Heating View Scheme
参考文献
Russian Chemical Bulletin, , vol. 58, # 6 p. 1233 - 1240
反应条件
sulfuric acid; sodium perchlorate in methanol T=25°C; various concentrations; Rate constantMechanism;
参考文献
Journal of Organic Chemistry, , vol. 49, # 22 p. 4295 - 4297
反应条件
1: With hydrogenchloride; sodium nitrite in water T=0°C; 0.416667 h; 2: With urea in water 0.25 h; 3: With potassium iodide in dichloromethane; water T=20°C;
参考文献
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH; CHIOSIS, Gabriela; TALDONE, Tony; SUN, Weilin
Patent: WO2011/44394 A1, 2011 ;
Location in patent: Page/Page column 110 ;
反应条件
1.1: triethylamine / tetrahydrofuran / 0.5 h / 20 °C 2.1: trifluoroacetic acid / 0.17 h / 110 °C / |Microwave irradiation 2.2: 4 h / |Reflux 3.1: acetic acid; ammonium cerium (IV) nitrate / water / 0.08 h / 20 °C 4.1: triethylamine; trichlorophosphate / 3 h / |Reflux View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 67, p. 373 - 383
反应条件
potassium carbonate in chlorobenzene
参考文献
Neurogen Corporation
Patent: US6177566 B1, 2001 ;
US 6177566 B1
参考文献
Renzi et al.
Gazzetta Chimica Italiana, 1956 , vol. 86, p. 1362,1364
