4-氟-2-(三氟甲基)苯甲酸甲酯合成路线 (共 3 条)
反应条件
1: 4-fluoro-2-trifluoromethylbenzoic acid With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane Heating / reflux; 2: methanol in dichloromethane 2 h;
参考文献
Wyeth
Patent: EP1000059 B1, 2004 ;
Location in patent: Page 31 ;
反应条件
in N-methyl-acetamide; methanol
参考文献
American Home Products Corporation
Patent: US6194407 B1, 2001 ;
US 6194407 B1
反应条件
in methanol; diethyl ether; chloroform 2 h;
参考文献
WO2010/122089 A1, ;
Page/Page column 63 ;