3,4-二甲氧基-5-硝基苯甲醛合成路线 （共 20 条）
反应条件
1: 4-hydroxy-3-methoxy-5-nitro-benzaldehyde With caesium carbonate in N,N-dimethyl-formamide 0.166667 h; Inert atmosphere; 2: methyl iodide in N,N-dimethyl-formamide T=20 - 100°C; Microwave irradiation;
参考文献
EXONHIT S.A.; LEBLOND, Bertrand; TAVERNE, Thierry; BEAUSOLEIL, Eric; CHAUVIGNAC, Cedric; CASAGRANDE, Anne-Sophie; DESIRE, Laurent
Patent: WO2011/151423 A1, 2011 ;
Location in patent: Page/Page column 236-237 ;
反应条件
sodium hydroxide; tetrabutylammomium bromide in dichloromethane; water 24 h;
参考文献
Bailey, Karl; Tan, Eng Wui
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 20 p. 5740 - 5749
反应条件
in tetrahydrofuran; diethyl ether Ambient temperature;
参考文献
Argentini, Mario; Wiese, Claudia; Weinreich, Regin
Journal of Fluorine Chemistry, 1994 , vol. 68, # 2 p. 141 - 144
反应条件
sulfuric acid; nitric acid T=-20°C; 168 h;
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 2 p. 556 - 568
反应条件
potassium carbonate in acetone 1.5 h; Reflux;
参考文献
Kiss, Laszlo E.; Ferreira, Humberto S.; Torrao, Leonel; Bonifacio, Maria Joao; Palma, P. Nuno; Soares-Da-Silva, Patricio; Learmonth, David A.
Journal of Medicinal Chemistry, 2010 , vol. 53, # 8 p. 3396 - 3411
反应条件
1: 80 percent / nitric acid; acetic acid / 0.5 h / 5 °C 2: 84 percent / sodium hydroxide; tetrabutylammonium bromide / CH2Cl2; H2O / 24 h View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 13, # 20 p. 5740 - 5749
反应条件
potassium carbonate T=100°C;
参考文献
Chemische Berichte, , vol. 35, p. 4398
反应条件
toluene T=135 - 140°C;
参考文献
Journal of the Chemical Society, , vol. 113, p. 24
参考文献
Journal of the Chemical Society, , vol. 125, p. 1062
反应条件
(i) K2CO3, acetone, (ii) aq. H2SO4, AcOH; Multistep reaction;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 16, p. 2343 - 2350
