2,2-联吡啶-5-甲胺合成路线 （共 10 条）
反应条件
1: With 1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane in dichloromethane Alkylation; 3 h; Heating; 2: With hydrogenchloride in ethanol T=80°C; Hydrolysis; 20 h;
参考文献
Panetta, Charles A.; Kumpaty, Hephzibah Jayasheela; Heimer, Norman E.; Leavy, Montray C.; Hussey
Journal of Organic Chemistry, 1999 , vol. 64, # 3 p. 1015 - 1021
反应条件
NiII chloride hexahydrate; iodine; acetic acid; lithium chloride; zinc in N,N-dimethyl-formamide T=50 - 70°C; 6 h;
参考文献
Liao, Lian-Yan; Kong, Xing-Rui; Duan, Xin-Fang
Journal of Organic Chemistry, 2014 , vol. 79, # 2 p. 777 - 782
反应条件
1.1: 84 percent / (PPh3)2PdCl2 / m-xylene / 7 h / 135 °C 2.1: 92 percent / lithium aluminum hydride / tetrahydrofuran / 1.5 h / -78 - -20 °C 3.1: 66 percent / NBS; PPh3 4.1: hexamethylenetetramine / CH2Cl2 / 3 h / Heating 4.2: 98 percent / conc. HCl / ethanol / 20 h / 80 °C View Scheme
参考文献
Panetta, Charles A.; Kumpaty, Hephzibah Jayasheela; Heimer, Norman E.; Leavy, Montray C.; Hussey
Journal of Organic Chemistry, 1999 , vol. 64, # 3 p. 1015 - 1021
反应条件
1.1: 84 percent / (PPh3)2PdCl2 / m-xylene / 7 h / 135 °C 2.1: 92 percent / lithium aluminum hydride / tetrahydrofuran / 1.5 h / -78 - -20 °C 3.1: 66 percent / NBS; PPh3 4.1: hexamethylenetetramine / CH2Cl2 / 3 h / Heating 4.2: 98 percent / conc. HCl / ethanol / 20 h / 80 °C View Scheme
参考文献
Panetta, Charles A.; Kumpaty, Hephzibah Jayasheela; Heimer, Norman E.; Leavy, Montray C.; Hussey
Journal of Organic Chemistry, 1999 , vol. 64, # 3 p. 1015 - 1021
反应条件
1: 1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane; 5-bromomethyl-2,2′ bipyridine in chloroform 4 h; RefluxInert atmosphere; 2: hydrogenchloride in ethanol; water T=80°C; 20 h; Reflux;
参考文献
Pallavicini, Piersandro; Dacarro, Giacomo; Grisoli, Pietro; Mangano, Carlo; Patrini, Maddalena; Rigoni, Federica; Sangaletti, Luigi; Taglietti, Angelo
Dalton Transactions, 2013 , vol. 42, # 13 p. 4552 - 4560
反应条件
1.1: 66 percent / NBS; PPh3 2.1: hexamethylenetetramine / CH2Cl2 / 3 h / Heating 2.2: 98 percent / conc. HCl / ethanol / 20 h / 80 °C View Scheme
参考文献
Panetta, Charles A.; Kumpaty, Hephzibah Jayasheela; Heimer, Norman E.; Leavy, Montray C.; Hussey
Journal of Organic Chemistry, 1999 , vol. 64, # 3 p. 1015 - 1021
反应条件
1.1: 92 percent / lithium aluminum hydride / tetrahydrofuran / 1.5 h / -78 - -20 °C 2.1: 66 percent / NBS; PPh3 3.1: hexamethylenetetramine / CH2Cl2 / 3 h / Heating 3.2: 98 percent / conc. HCl / ethanol / 20 h / 80 °C View Scheme
参考文献
Panetta, Charles A.; Kumpaty, Hephzibah Jayasheela; Heimer, Norman E.; Leavy, Montray C.; Hussey
Journal of Organic Chemistry, 1999 , vol. 64, # 3 p. 1015 - 1021
反应条件
1: iodine 2: ammonium acetate; formamide 3: N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile / tetrachloromethane 4: 1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane / dichloromethane View Scheme
参考文献
Bos, Jeffrey; Fusetti, Fabrizia; Driessen, Arnold J. M.; Roelfes, Gerard
Angewandte Chemie - International Edition, 2012 , vol. 51, # 30 p. 7472 - 7475
反应条件
1: ammonium acetate; formamide 2: N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile / tetrachloromethane 3: 1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane / dichloromethane View Scheme
参考文献
Bos, Jeffrey; Fusetti, Fabrizia; Driessen, Arnold J. M.; Roelfes, Gerard
Angewandte Chemie - International Edition, 2012 , vol. 51, # 30 p. 7472 - 7475
反应条件
1: N-bromosuccinmide; 2,2'-azo-bisisobutyronitrile / tetrachloromethane 2: 1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane / dichloromethane View Scheme
参考文献
Bos, Jeffrey; Fusetti, Fabrizia; Driessen, Arnold J. M.; Roelfes, Gerard
Angewandte Chemie - International Edition, 2012 , vol. 51, # 30 p. 7472 - 7475
