4-溴-2,1,3-苯并噻二唑合成路线 （共 9 条）
反应条件
hydrogen bromide; bromine in water T=12°C; Reflux;
参考文献
Lirag, Rio Carlo; Le, Ha T. M.; Miljanic, Ognjen S.
Chemical Communications, 2013 , vol. 49, # 39 p. 4304 - 4306
反应条件
1.1: thionyl chloride / toluene / 3 h / Reflux 1.2: 19 h / Reflux 2.1: hydrogen bromide; bromine / 3 h / Reflux View Scheme
参考文献
Journal of Physical Chemistry B, , vol. 116, # 24 p. 7259 - 7268
反应条件
(i) NaNO2, aq. HBr, (ii) CuBr; Multistep reaction;
参考文献
J. Gen. Chem. USSR (Engl. Transl.), , vol. 33, # 6 p. 1759 - 1766,1714 - 1719
反应条件
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate in 1,4-dioxane T=105°C; 20 h; Inert atmosphere;
参考文献
Anant, Piyush; Lucas, Nigel T.; Jacob, Josemon
Organic Letters, 2008 , vol. 10, # 24 p. 5533 - 5536
反应条件
1: With sodium tetrahydroborate; CoCl2.6H2O in methanol 3 h; Reflux; 2: With water
参考文献
Wasik, Romualda; Winska, Patrycja; Poznanski, Jaroslaw; Shugar, David
Journal of Physical Chemistry B, 2012 , vol. 116, # 24 p. 7259 - 7268
反应条件
1: SO3/H2SO4 / 125 - 130 °C 2: aq. Br2 View Scheme
参考文献
Mikhailitsyn,F.S.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1973 , vol. 9, p. 293 - 295
Khimiya Geterotsiklicheskikh Soedinenii, 1973 , vol. 9, # 3 p. 319 - 321
反应条件
1: HNO3, H2SO4 / 0 °C
2: NaNO3, H2SO4 / 95 - 100 °C
View Scheme
参考文献
Pesin,V.G. et al.
J. Gen. Chem. USSR (Engl. Transl.), 1963 , vol. 33, # 6 p. 1759 - 1766,1714 - 1719
反应条件
1: SO3/H2SO4 / 125 - 130 °C
2: ClSO3H / 140 °C
3: Na2SO3, aq. NaOH
View Scheme
参考文献
Mikhailitsyn,F.S.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1973 , vol. 9, p. 293 - 295
Khimiya Geterotsiklicheskikh Soedinenii, 1973 , vol. 9, # 3 p. 319 - 321
反应条件
chlorosulfonic acid
T=140°C;
参考文献
Mikhailitsyn,F.S.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1973 , vol. 9, p. 293 - 295
Khimiya Geterotsiklicheskikh Soedinenii, 1973 , vol. 9, # 3 p. 319 - 321
