(R)-(-)-alpha-(三氟甲基)苄胺合成路线 （共 8 条）
反应条件
hydrogen; acetic acid; palladium on activated charcoal in diethyl ether T=20 - 25°C; P=2068.6 - 2327.2 Torr;
参考文献
Wang; Mosher
Tetrahedron Letters, 1991 , vol. 32, # 8 p. 987 - 990
反应条件
1: With L-(+)-tartaric acid in isopropyl alcohol 0.5 h; Reflux; 2: With sodium carbonate in water
参考文献
GLAXOSMITHKLINE LLC; BROOKS, Carl, A.; CHEUNG, Mui; EIDAM, Hilary, S.; FOX, Ryan, M.; HILFIKER, Mark, A.; MANAS, Eric, S.; YE, Guosen
Patent: WO2011/119701 A1, 2011 ;
Location in patent: Page/Page column 40 ;
WO 2011/119701 A1
反应条件
ammonium cerium (IV) nitrate in methanol; water T=0°C; 6 h;
参考文献
Chen, Mu-Wang; Duan, Ying; Chen, Qing-An; Wang, Duo-Sheng; Yu, Chang-Bin; Zhou, Yong-Gui
Organic Letters, 2010 , vol. 12, # 21 p. 5075 - 5077
反应条件
hydrogenchloride; hydrogen in diethyl ether T=70°C; P=7500.75 Torr; Title compound not separated from byproducts.;
参考文献
Advanced Synthesis and Catalysis, , vol. 345, # 1-2 p. 165 - 168
反应条件
L-(+)-tartaric acid in isopropyl alcohol T=20 - 70°C; Resolution of racemate; Purification / work up;
参考文献
SENEXIS LIMITED; BTG INTERNATIONAL LIMITED; SCOPES, David
Patent: WO2011/42496 A1, 2011 ;
Location in patent: Page/Page column 16 ;
WO 2011/042496 A1
反应条件
1: 94 percent / NH2OH*HCl, NaOAc / H2O; ethanol / 10 h / 75 °C 2: 70 percent / H2, AcOH / 10percent Pd/C / diethyl ether / 20 - 25 °C / 2068.6 - 2327.2 Torr View Scheme
参考文献
Tetrahedron Letters, , vol. 32, # 8 p. 987 - 990
反应条件
hydrogenchloride in diethyl ether Ambient temperature;
参考文献
Journal of Organic Chemistry, , vol. 62, # 10 p. 3030 - 3031
反应条件
lead(IV) acetate 1.) THF, 0 deg C, 0.5 h, to rt, 16 h, 2.) benzene, rt, 16 h; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Synlett, , # 12 p. 1381 - 1382
