Cbz-4-碘-L-苯基丙氨酸合成路线 （共 4 条）
反应条件
sodium hydroxide 1 h; Ambient temperature;
参考文献
Castilla, Ana Maria; Ballester, Pablo; Conn, M. Morgan
Beilstein Journal of Organic Chemistry, 2010 , vol. 6, art. no. 5
反应条件
1: 53 percent / I2, NaIO3, conc. H2SO4 / acetic acid / 21 h / 70 °C 2: 91 percent / aq. NaOH / 1 h / Ambient temperature View Scheme
参考文献
Lei, Haiyan; Stoakes, Mark S.; Herath, Kamal P. B.; Lee, Jinho; Schwabacher, Alan W.
Journal of Organic Chemistry, 1994 , vol. 59, # 15 p. 4206 - 4210
反应条件
1: 97 percent / p-TsOH*H2O / toluene / 3 h / Heating 2: 72 percent / Et3N / [PdCl2(dppf)] / dioxane / 27 h / 80 °C 3: NaIO4; NH4OAc / acetone; H2O / 48 h / 20 °C 4: 1.30 g / aq. NaOH / 1 h 5: 63 percent / hydrogen; aq. HCl / Pd(OH)2/C / ethanol / 19 h / 20 °C View Scheme
参考文献
Nakamura, Hiroyuki; Fujiwara, Masaru; Yamamoto, Yoshinori
Bulletin of the Chemical Society of Japan, 2000 , vol. 73, # 1 p. 231 - 235
反应条件
1.1: potassium carbonate; tetrabutylammonium iodide / acetone / 0.5 h / 20 °C
1.2: 2.86 g / acetone / 2 h / Heating
2.1: 92 percent / Pd(dppf)Cl2*CH2Cl2; KOAc / dimethylsulfoxide / 4.5 h / 80 °C
3.1: 50 percent / H2O / 72 h / 20 °C
View Scheme
参考文献
Nakamura, Hiroyuki; Fujiwara, Masaru; Yamamoto, Yoshinori
Bulletin of the Chemical Society of Japan, 2000 , vol. 73, # 1 p. 231 - 235
