2-氯-4-(3-甲基-1H-吡唑-1-基)苯甲酸合成路线 (共 4 条)
反应条件
hydrogenchloride; water; acetic acid 6 h; Reflux;
参考文献
Frantz, Marie-Celine; Rodrigo, Jordi; Boudier, Laure; Durroux, Thierry; Mouillac, Bernard; Hibert, Marcel
Journal of Medicinal Chemistry, 2010 , vol. 53, # 4 p. 1546 - 1562
参考文献
American Home Products Corporation
Patent: US6194407 B1, 2001 ;
US 6194407 B1
反应条件
sulfuric acid; water; sodium nitrite T=0 - 20°C; 1 h;
参考文献
American Cyanamid Company
Patent: US6831079 B1, 2004 ;
Location in patent: Page/Page column 48 ;
US 6831079 B1
反应条件
1: 61 percent / K2CO3 / 1-methyl-pyrrolidin-2-one / 5 h / 120 °C 2: 97 percent / 6 N aq. HCl; AcOH / 4 h / Heating View Scheme
参考文献
Kondo; Ogawa; Shinohara; Kurimura; Tanada; Kan; Yamashita; Nakamura; Hirano; Yamamura; Mori; Tominaga; Itai
Journal of Medicinal Chemistry, 2000 , vol. 43, # 23 p. 4388 - 4397