2-(1-丙炔-1-基)苯胺合成路线 （共 7 条）
反应条件
copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride in triethylamine T=20°C; Arylation; 27 h;
参考文献
Zhang; Shi; Wang
Journal of Organic Chemistry, 2000 , vol. 65, # 23 p. 7977 - 7983
反应条件
lithium diisopropyl amide in tetrahydrofuran
参考文献
Miyagi, Takashi; Hari, Yoshiyuki; Aoyama, Toyohiko
Tetrahedron Letters, 2004 , vol. 45, # 33 p. 6303 - 6305
反应条件
copper(l) iodide in N,N-dimethyl-formamide 4 h; Heating;
参考文献
Kuyper, Lee F.; Baccanari, David P.; Jones, Michael L.; Hunter, Robert N.; Tansik, Robert L.; Joyner, Suzanne S.; Boytos, Christine M.; Rudolph, Sharon K.; Knick, Vince; Wilson, H. Robert; Caddell, J. Marc; Friedman, Henry S.; Comley, John C. W.; Stables, Jeremy N.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 4 p. 892 - 903
反应条件
1: CuI / dimethylformamide / 4 h / Heating 2: NaH / dimethylformamide View Scheme
参考文献
Kuyper, Lee F.; Baccanari, David P.; Jones, Michael L.; Hunter, Robert N.; Tansik, Robert L.; Joyner, Suzanne S.; Boytos, Christine M.; Rudolph, Sharon K.; Knick, Vince; Wilson, H. Robert; Caddell, J. Marc; Friedman, Henry S.; Comley, John C. W.; Stables, Jeremy N.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 4 p. 892 - 903
反应条件
1: CuI / dimethylformamide / 4 h / Heating
2: 1.) NaH / 1.) DMF, 1 h, 2.) DMF, 8 h
View Scheme
参考文献
Kuyper, Lee F.; Baccanari, David P.; Jones, Michael L.; Hunter, Robert N.; Tansik, Robert L.; Joyner, Suzanne S.; Boytos, Christine M.; Rudolph, Sharon K.; Knick, Vince; Wilson, H. Robert; Caddell, J. Marc; Friedman, Henry S.; Comley, John C. W.; Stables, Jeremy N.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 4 p. 892 - 903
反应条件
1: CuI / dimethylformamide / 4 h / Heating
2: NaH / dimethylformamide
3: 79 percent / NaNO3, H2SO4 / 1.) 0 deg C, 5h, 2.) RT, 12 h
4: H2 / 10percent Pd/C / methanol / 2 h / 2068.6 Torr
View Scheme
参考文献
Kuyper, Lee F.; Baccanari, David P.; Jones, Michael L.; Hunter, Robert N.; Tansik, Robert L.; Joyner, Suzanne S.; Boytos, Christine M.; Rudolph, Sharon K.; Knick, Vince; Wilson, H. Robert; Caddell, J. Marc; Friedman, Henry S.; Comley, John C. W.; Stables, Jeremy N.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 4 p. 892 - 903
反应条件
1: CuI / dimethylformamide / 4 h / Heating
2: NaH / dimethylformamide
3: 79 percent / NaNO3, H2SO4 / 1.) 0 deg C, 5h, 2.) RT, 12 h
View Scheme
参考文献
Kuyper, Lee F.; Baccanari, David P.; Jones, Michael L.; Hunter, Robert N.; Tansik, Robert L.; Joyner, Suzanne S.; Boytos, Christine M.; Rudolph, Sharon K.; Knick, Vince; Wilson, H. Robert; Caddell, J. Marc; Friedman, Henry S.; Comley, John C. W.; Stables, Jeremy N.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 4 p. 892 - 903
