2-甲基-3-硝基-5-溴苯甲酸甲酯合成路线 （共 9 条）
反应条件
sodium carbonate in N,N-dimethyl-formamide T=60°C; 8 h;
参考文献
Kuntz, Kevin Wayne; Campbell, John Emmerson; Seki, Masashi
Patent: US2014/107122 A1, 2014 ;
Location in patent: Paragraph 0159; 0160 ;
反应条件
thionyl chloride Reflux;
参考文献
CELGENE CORPORATION; TRAVERSE, John, F.; FEIGELSON, Gregg, Brian; RUCHELMAN, Alexander, L.; LIU, Jihong; LIU, Hongfeng; MA, Chengjun; LIU, Danyang; ZHANG, Steven
Patent: WO2014/18866 A1, 2014 ;
Location in patent: Paragraph 00181; 00183 ;
反应条件
1: 1,3-dibromo-5,5-dimethyl-hydantoin; sulfuric acid / 5 h / 20 °C 2: sodium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C View Scheme
参考文献
WO2012/118812 A2, ;
WO 2012/118812 A2
US2012/264734 A1, ;
US 20120264734 A1
反应条件
1: nitric acid; sulfuric acid / acetone / 2.25 h / -5 - 0 °C / Cooling with acetone-ice 2: sodium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C View Scheme
参考文献
US2012/264734 A1, ;
US 20120264734 A1
反应条件
sodium carbonate; palladium diacetate; triphenylphosphine in ethylene glycol dimethyl ether; water T=90°C; 6 h;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2008/16184 A1, 2008 ;
Location in patent: Page/Page column 185-186 ;
反应条件
1.1: ammonium chloride; iron / ethanol; water / 1 h / 90 °C 2.1: potassium acetate / chloroform / 12 h / 20 °C 2.2: 3 h / 65 °C 3.1: hydrogenchloride / water; methanol / 8 h / 60 °C 3.2: pH 8 View Scheme
参考文献
EPIZYME, INC.; KUNTZ, Kevin, Wayne; OLHAVA, Edward, James; CHESWORTH, Richard; DUNCAN, Kenneth, William
Patent: WO2012/118812 A2, 2012 ;
WO 2012/118812 A2
反应条件
iron; ammonium chloride in ethanol; water T=90°C; 1 h;
参考文献
EPIZYME, INC.; KUNTZ, Kevin, Wayne; OLHAVA, Edward, James; CHESWORTH, Richard; DUNCAN, Kenneth, William
Patent: WO2012/118812 A2, 2012 ;
Location in patent: Page/Page column 312 ;
WO 2012/118812 A2
反应条件
1.1: ammonium chloride; iron / ethanol; water / 1 h / 90 °C 2.1: potassium acetate / chloroform / 12 h / 20 °C 2.2: 3 h / 65 °C View Scheme
参考文献
EPIZYME, INC.; KUNTZ, Kevin, Wayne; OLHAVA, Edward, James; CHESWORTH, Richard; DUNCAN, Kenneth, William
Patent: WO2012/118812 A2, 2012 ;
WO 2012/118812 A2
反应条件
1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II) dichloromethane adduct / 1,4-dioxane / |Reflux; |Inert atmosphere
2: Oxone® / acetone; water / 1 h / 20 °C / |Cooling with ice
View Scheme
参考文献
CELGENE CORPORATION; TRAVERSE, John, F.; FEIGELSON, Gregg, Brian; RUCHELMAN, Alexander, L.; LIU, Jihong; LIU, Hongfeng; MA, Chengjun; LIU, Danyang; ZHANG, Steven
Patent: WO2014/18866 A1, 2014 ;
