1: methyl isocyanate With n-butyllithium in tetrahydrofuran; hexane T=-78°C; Metallation; 0.25 h; 2: 3-phenyl-propionic acid ethyl ester in tetrahydrofuran; hexane T=-78 - 20°C; Cyclization; 3 h;

disodium hydrogenphosphate; sodium amalgam in tetrahydrofuran; ethanol Reduction; Desulfonylation; 4 h; Sonication;

1.1: n-BuLi / hexane; tetrahydrofuran / 0.25 h / -78 °C 1.2: 85 percent / hexane; tetrahydrofuran / 2.5 h / -78 - 20 °C 2.1: 72 percent / Na2HPO4; Na/Hg / tetrahydrofuran; ethanol / 4 h / Sonication View Scheme