2,2-二甲基-苯并二氢吡喃-4-胺合成路线 （共 3 条）
反应条件
1: With acetic acid; zinc 4 - 8 h; Reflux; 2: With sodium hydroxide in water T=20°C; pH=9 - 11;
参考文献
GLENMARK PHARMACEUTICALS S.A.
Patent: WO2008/59339 A2, 2008 ;
Location in patent: Page/Page column 25 ;
WO 2008/059339 A2
反应条件
1: With ammonium acetate; sodium cyanoborohydride in methanol 24 h; 2: With hydrogenchloride in methanol; water pH=< 1; 3: With potassium hydroxide in methanol; water
参考文献
PHARMACOPEIA DRUG DISCOVERY, INC.
Patent: WO2006/108103 A1, 2006 ;
Location in patent: Page/Page column 123 ;
反应条件
1: With water; tin(ll) chloride in methanol T=20°C; 14 h; 2: With sodium hydrogencarbonate in water Saturated solution;
参考文献
Askew, Benny C.; Aya, Toshihiro; Biswas, Kaustav; Cai, Guolin; Chen, Jian J.; Han, Nianhe; Liu, Qingyian; Nguyen, Thomas; Nishimura, Nobuko; Nomak, Rana; Peterkin, Tanya; Qian, Wenyuan; Yang, Kevin; Yuan, Chester Chenguang; Zhu, Jiawang; D' Amico, Derin C.; Human, Jason B.; Huang, Qi
Patent: US2006/25400 A1, 2006 ;
Location in patent: Page/Page column 40 ;
US 20060025400 A1
