bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine in tetrahydrofuran Sonogashira Cross-Coupling; 0.0833333 h; Inert atmosphere;

copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride in N,N-dimethyl-formamide T=20°C; Sonogashira reaction;

1: 60 percent / copper(I) iodide / Pd(PPh3)2Cl2 / diethylamine / 168 h / Heating 2: 96 percent / KOH / dimethylsulfoxide 3: 96 percent / aq. HCl / tetrahydrofuran / 4 h / 20 °C View Scheme

bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine T=20°C; Sonogashira coupling; Inert atmosphere;