1: ethyl 2-(2-chloronicotinoyl)acetate; ethyl-3,3-dimethylaminoacrylate With triethylamine in acetonitrile 3 h; Heating / reflux; 2: 3-bromo-aniline in acetonitrile Heating / reflux;

1.1: acetic anhydride / acetic anhydride / 2.5 h / 130 °C 1.2: 18 h / 20 °C 2.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / 0 °C View Scheme