1-(甲氧基甲基)环戊烷羧酸合成路线 （共 5 条）
反应条件
1: With ethanol; potassium hydroxide
T=80°C; 6 h;
2: With hydrogenchloride in water
参考文献
HETERO RESEARCH FOUNDATION; PARTHASARADHI REDDY, Bandi; VAMSI KRISHNA, Bandi; MANOHAR SHARMA, Vedula; RATHNAKAR REDDY, Kura; MADHANMOHAN REDDY, Musku; VL SUBRAHMANYAM, Lanka; PREM KUMAR, Mamnoor
Patent: WO2011/61590 A1, 2011 ;
Location in patent: Page/Page column 31 ;
反应条件
sodium hydroxide in tetrahydrofuran; methanol
15 h; Heating;
参考文献
Sidduri, Achyutharao; Tilley, Jefferson W; Hull, Kenneth; Lou, Jian Ping; Kaplan, Gerry; Sheffron, Allen; Chen; Campbell, Robert; Guthrie, Robert; Huang, Tai-Nan; Huby, Nicholas; Rowan, Karen; Schwinge, Virginia; Renzetti, Louis M
Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 17 p. 2475 - 2478
反应条件
1: LDA / tetrahydrofuran / 15 h / -70 - 20 °C
2: 1.0 N NaOH / methanol; tetrahydrofuran / 15 h / Heating
View Scheme
参考文献
Sidduri, Achyutharao; Tilley, Jefferson W; Hull, Kenneth; Lou, Jian Ping; Kaplan, Gerry; Sheffron, Allen; Chen; Campbell, Robert; Guthrie, Robert; Huang, Tai-Nan; Huby, Nicholas; Rowan, Karen; Schwinge, Virginia; Renzetti, Louis M
Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 17 p. 2475 - 2478
反应条件
1.1: sulfuric acid / 6 h / 80 °C
2.1: diisopropylamine; n-butyllithium / tetrahydrofuran / 1.25 h / -75 - -35 °C / Inert atmosphere
2.2: -75 - 20 °C / Inert atmosphere
3.1: potassium hydroxide; ethanol / 6 h / 80 °C
View Scheme
参考文献
HETERO RESEARCH FOUNDATION; PARTHASARADHI REDDY, Bandi; VAMSI KRISHNA, Bandi; MANOHAR SHARMA, Vedula; RATHNAKAR REDDY, Kura; MADHANMOHAN REDDY, Musku; VL SUBRAHMANYAM, Lanka; PREM KUMAR, Mamnoor
Patent: WO2011/61590 A1, 2011 ;
反应条件
1.1: diisopropylamine; n-butyllithium / tetrahydrofuran / 1.25 h / -75 - -35 °C / Inert atmosphere
1.2: -75 - 20 °C / Inert atmosphere
2.1: potassium hydroxide; ethanol / 6 h / 80 °C
View Scheme
参考文献
HETERO RESEARCH FOUNDATION; PARTHASARADHI REDDY, Bandi; VAMSI KRISHNA, Bandi; MANOHAR SHARMA, Vedula; RATHNAKAR REDDY, Kura; MADHANMOHAN REDDY, Musku; VL SUBRAHMANYAM, Lanka; PREM KUMAR, Mamnoor
Patent: WO2011/61590 A1, 2011 ;
