4-(1-吡咯烷基)苯甲酸合成路线 （共 8 条）
反应条件
1: thionyl chloride / -10 - 20 °C 2: potassium carbonate; tBuNH2·BH3 / 1,4-dioxane; water / 48 h / |Reflux 3: sodium hydroxide; water / methanol / |Reflux View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 19 p. 8524 - 8537,14
反应条件
1: potassium carbonate; tBuNH2·BH3 / 1,4-dioxane; water / 48 h / |Reflux 2: sodium hydroxide; water / methanol / |Reflux View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 55, # 19 p. 8524 - 8537,14
反应条件
water; sodium hydroxide in methanol Reflux;
参考文献
Liu, Xia; Chan, Chi-Bun; Qi, Qi; Ye, Keqiang; Xiao, Ge; Luo, Hongbo R.; He, Xiaolin
Journal of Medicinal Chemistry, 2012 , vol. 55, # 19 p. 8524 - 8537,14
反应条件
1: chloroform 2: aqueous alkaline solution View Scheme
参考文献
Justus Liebigs Annalen der Chemie, , vol. 596, p. 1,146
反应条件
n-butyllithium; diethyl ether Behandeln des Reaktionsgemisches mit Kohlendioxid.;
参考文献
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, , p. 166,167, 170
Chem.Abstr., , p. 10236
参考文献
Justus Liebigs Annalen der Chemie, , vol. 596, p. 1,146
反应条件
1-methyl-pyrrolidin-2-one; thionyl chloride in dichloromethane
T=20°C;
参考文献
Liu, Xia; Chan, Chi-Bun; Qi, Qi; Ye, Keqiang; Xiao, Ge; Luo, Hongbo R.; He, Xiaolin
Journal of Medicinal Chemistry, 2012 , vol. 55, # 19 p. 8524 - 8537,14
反应条件
4-(N,N-dimethlyamino)pyridine; benzotriazol-1-ol; N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide; pyridine
T=20°C;
参考文献
SK CHEMICALS, CO., LTD.; IN2GEN CO., LTD.
Patent: WO2003/87066 A1, 2003 ;
Location in patent: Page/Page column 14-15 ;
WO 03/087066 A1
