2-溴-5-(1,3-二氧杂烷-2-基)吡啶合成路线 （共 6 条）
反应条件
toluene-4-sulfonic acid in benzene Reflux;
参考文献
Carberry, Patrick; Carpenter, Alan P.; Kung, Hank F.
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 23 p. 6992 - 6995
反应条件
toluene-4-sulfonic acid in ethylene glycol; toluene
参考文献
Raeppel, Stëphane; Raeppel, Franck; Claridge, Stephen William; Zhan, Lijie; Gaudette, Frëdëric; Mannion, Michael; Sato, Norifumi; Yuki, Yohei; Kishida, Masashi; Vaisburg, Arkadii
Patent: US2011/257100 A1, 2011 ;
US 20110257100 A1
反应条件
n-butyllithium in diethyl ether; hexane (Ar), ligand in diethyl ether cooled to -78°C, slowly treated with n-BuLi in hexane for 10 min, kept for 1.5 h with stirring, treated with Sn complex for 5 min, cooled at -78°C for 120 min; warmed to room temp. overnight, filtered, evapd.(vac.);
参考文献
Zoppellaro, Giorgio; Ivanova, Anela; Enkelmann, Volker; Geies, Ahmed; Baumgarten, Martin
Polyhedron, 2003 , vol. 22, # 14-17 p. 2099 - 2110
反应条件
1: tetrakis(triphenylphosphine) palladium(0) / 12 h / 80 °C / |Inert atmosphere 2: hydrogenchloride; water / tetrahydrofuran / 29 h / 20 - 50 °C / |Inert atmosphere View Scheme
参考文献
Kyowa Hakko Kirin Co., Ltd.; Fukuda, Yuichi; Kanai, Toshimi; Nakasato, Yoshisuke; Kimpara, Keisuke
Patent: US2013/65905 A1, 2013 ;
反应条件
1: With tetrakis(triphenylphosphine) palladium(0) in DMF (N,N-dimethyl-formamide)
T=80°C; 18 h;
2: With tetrakis(triphenylphosphine) palladium(0) in DMF (N,N-dimethyl-formamide)
T=80°C; 18 h;
3: in DMF (N,N-dimethyl-formamide)
T=20°C; 48 h;
参考文献
BAYER HEALTHCARE AG
Patent: WO2004/24700 A1, 2004 ;
Location in patent: Page 34 ;
WO 2004/024700 A1
反应条件
tetrakis(triphenylphosphine) palladium(0)
T=80°C; 12 h; Inert atmosphere;
参考文献
Kyowa Hakko Kirin Co., Ltd.; Fukuda, Yuichi; Kanai, Toshimi; Nakasato, Yoshisuke; Kimpara, Keisuke
Patent: US2013/65905 A1, 2013 ;
Location in patent: Paragraph 0181 ;
