potassium hydroxide in methanol; water T=20°C; 12 h;

1: 70 percent / tetrabutylammonium bromide; KOAc; molecular sieves 4 Angstroem / Pd(OAc)2 / dimethylformamide / 8 h / 20 °C 2: 95 percent / KOH / methanol; H2O / 12 h / 20 °C View Scheme

1: 66 percent / Cs2CO3; NaI / acetonitrile / 12 h / 65 °C 2: 70 percent / tetrabutylammonium bromide; KOAc; molecular sieves 4 Angstroem / Pd(OAc)2 / dimethylformamide / 8 h / 20 °C 3: 95 percent / KOH / methanol; H2O / 12 h / 20 °C View Scheme

1: 66 percent / Cs2CO3; NaI / acetonitrile / 12 h / 65 °C 2: 70 percent / tetrabutylammonium bromide; KOAc; molecular sieves 4 Angstroem / Pd(OAc)2 / dimethylformamide / 8 h / 20 °C 3: 95 percent / KOH / methanol; H2O / 12 h / 20 °C View Scheme