1: 2-methyl propanoic acid With lithium diisopropyl amide in tetrahydrofuran; n-heptane; ethylbenzene T=-25 - 50°C; 2: 1,6-dibromo-n-hexane in tetrahydrofuran; n-heptane; ethylbenzene T=-30 - 40°C;
参考文献
Decker, Michael; Fulton, Brian S.; Zhang, Bin; Knapp, Brian I.; Bidlack, Jean M.; Neumeyer, John L.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 23 p. 7389 - 7396