1-苄基-4-丁基哌啶-4-醇合成路线 (共 4 条)
反应条件
1: n-butyllithium; 2-[2-(2-bromophenyl)vinyl]-1,3-dioxolane in tetrahydrofuran; hexane T=-78°C; 0.166667 h; Inert atmosphere; 2: 1-Phenylmethyl-piperidin-4-one in tetrahydrofuran; hexane T=-78 - 20°C; 18 h; Inert atmosphere; 3: With water in tetrahydrofuran; hexane Inert atmosphere;
参考文献
Maestrup, Eva Grosse; Wiese, Christian; Schepmann, Dirk; Brust, Peter; Wuensch, Bernhard
Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 1 p. 393 - 405
反应条件
1: in diethyl ether; hexane T=0 - 20°C; 2: With water in diethyl ether; hexane
参考文献
Kelly, Nicholas Michael; Koch, Kristian Norup; Tolf, Bo-Ragnar
Patent: US2004/67931 A1, 2004 ;
Location in patent: Page/Page column 38 ;
反应条件
n-butyllithium in diethyl ether; hexane; ethyl acetate
参考文献
Abreo, Melwyn A.; Meng, Jerry J.; Agree, Charles S.
Patent: US2002/65292 A1, 2002 ;
反应条件
1: n-butyl-magnesium chloride; 2-Bromobenzoic acid With n-butyllithium 2: 1-Phenylmethyl-piperidin-4-one Reagent/catalystConcentration;
参考文献
Itoh, Takahiro; Kato, Shinji; Nonoyama, Nobuaki; Wada, Toshihiro; Maeda, Kenji; Mase, Toshiaki; Zhao, Matthew M.; Song, Jake Z.; Tschaen, David M.; McNamara, James M.
Organic Process Research and Development, 2006 , vol. 10, # 4 p. 822 - 828