1,3-二溴-2,2-二甲氧基丙烷合成路线 （共 9 条）
反应条件
bromine T=0 - 25°C; 25 h;
参考文献
Berthel, Steven Joseph; Kester, Robert Francis; Murphy, Douglas Eric; Prins, Thomas Jay; Ruebsam, Frank; Sarabu, Ramakanth; Tran, Chinh Viet; Vourloumis, Dionisios
Patent: US2008/21032 A1, 2008 ;
Location in patent: Page/Page column 83 ;
US 20080021032 A1
反应条件
silver trifluoroacetate; sodium carbonate
参考文献
Journal of the American Chemical Society, , vol. 96, p. 4597 - 4603
参考文献
Chemische Berichte, , vol. 68, p. 1866 Anm.4
反应条件
bromine 1.) -20 deg C, 2.) electrolysis, 2.5 F/mol; Yield given. Multistep reaction;
参考文献
Synthetic Communications, , vol. 10, # 11 p. 821 - 826
反应条件
bromine 24 h; other time; Product distribution;
参考文献
Journal of Organic Chemistry, , vol. 46, # 12 p. 2532 - 2538
反应条件
sodium hydride 1.) DMF, 2.) 130 deg C, 40 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Pigou, Paul E.; Schiesser, Carl H.
Journal of Organic Chemistry, 1988 , vol. 53, # 16 p. 3841 - 3843
反应条件
1: malonic acid diisopropyl ester With sodium hydride in N,N-dimethyl-formamide T=70°C; 2: 1,3-Dibromoacetone Dimethyl Ketal in N,N-dimethyl-formamide T=140°C; 48 h;
参考文献
INCYTE CORPORATION
Patent: US2009/233903 A1, 2009 ;
Location in patent: Page/Page column 46 ;
US 20090233903 A1
反应条件
1: malonic acid diisopropyl ester With sodium hydride in DMF (N,N-dimethyl-formamide) T=70°C; 2: 1,3-Dibromoacetone Dimethyl Ketal T=140°C; 48 h;
参考文献
MERCK and CO. INC.
Patent: WO2004/82682 A1, 2004 ;
Location in patent: Page 35 ;
WO 2004/082682 A1
反应条件
sodium hydride 1.) DMF, 2.) 130 deg C, 40 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Pigou, Paul E.; Schiesser, Carl H.
Journal of Organic Chemistry, 1988 , vol. 53, # 16 p. 3841 - 3843
