pyridine hydrogenfluoride in tetrahydrofuran 2 h; Ambient temperature;

1: 91 percent / HF-pyridine / tetrahydrofuran / 2 h / Ambient temperature 2: 75 percent / H2O2, NaHCO3 / tetrahydrofuran / 16 h / Ambient temperature View Scheme

<b>Multi-step reaction with 2 steps<br /> </b>1: 98 percent / CHCl₃ / 3 h / Ambient temperature<br />2: 75 percent Turnov_. / Mg(OMe)2 / methanol / 0.75 h / Ambient temperature<br /> <br /> &nbsp;

Stage #1: <a href="#" onclick="return RXDsubstances(event, this, '1732860', constants.ctx, '0')">triethylsilyl chloride</a>; <a href="#" onclick="return RXDsubstances(event, this, '9467276', constants.ctx, '0')">2'-TBS-docetaxel</a> <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '103853', constants.ctx, '0')">1H-imidazole</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '110354', constants.ctx, '0')">4-(N,N-dimethlyamino)pyridine</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1730800', constants.ctx, '0')">dichloromethane</a> <br />T=20&deg;C;&nbsp;24&nbsp;h;&nbsp;<br />Stage #2: <a href="#" onclick="return RXDsubstances(event, this, '385737', constants.ctx, '0')">acetic anhydride</a> <b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '103233', constants.ctx, '0')">pyridine</a> <br />T=0 - 20&deg;C;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 1.) dimethylaminopyridine, 2.) imidazole / 1.) CH₂Cl₂, 2.) CH₂Cl₂ <br />2: 21 percent / dimethylaminopyridine / acetonitrile / 24 h / Ambient temperature<br />3: 75 percent Turnov_. / Mg(OMe)2 / methanol / 0.75 h / Ambient temperature<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 21 percent / dimethylaminopyridine / acetonitrile / 24 h / Ambient temperature<br />2: 75 percent Turnov_. / Mg(OMe)2 / methanol / 0.75 h / Ambient temperature<br /> <br /> &nbsp;