2,7-二氯-6-甲基-4-[(4-甲基-1-哌啶基)甲基]-3-喹啉甲醇合成路线 （共 5 条）
反应条件
in tetrahydrofuran
T=20°C; Alkylation;
参考文献
Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
Patent: US6339091 B1, 2002 ;
Location in patent: Example 82 ;
反应条件
1: Et3N / acetonitrile / 20 °C
2: 83 percent / EtONa / ethanol / 20 °C
3: 85 percent / POCl3 / Heating
4: 74 percent / Dibal / CH2Cl2 / 20 °C
5: 93 percent / tetrahydrofuran / 20 °C
View Scheme
参考文献
Lavergne, Olivier; Harnett, Jeremiah; Rolland, Alain; Lanco, Christophe; Lesueur-Ginot, Laurence; Demarquay, Daniele; Huchet, Marion; Coulomb, Helene; Bigg, Dennis C. H.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 17 p. 2599 - 2602
反应条件
1: 74 percent / Dibal / CH2Cl2 / 20 °C
2: 93 percent / tetrahydrofuran / 20 °C
View Scheme
参考文献
Lavergne, Olivier; Harnett, Jeremiah; Rolland, Alain; Lanco, Christophe; Lesueur-Ginot, Laurence; Demarquay, Daniele; Huchet, Marion; Coulomb, Helene; Bigg, Dennis C. H.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 17 p. 2599 - 2602
反应条件
1: 85 percent / POCl3 / Heating
2: 74 percent / Dibal / CH2Cl2 / 20 °C
3: 93 percent / tetrahydrofuran / 20 °C
View Scheme
参考文献
Lavergne, Olivier; Harnett, Jeremiah; Rolland, Alain; Lanco, Christophe; Lesueur-Ginot, Laurence; Demarquay, Daniele; Huchet, Marion; Coulomb, Helene; Bigg, Dennis C. H.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 17 p. 2599 - 2602
参考文献
Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
Patent: US6339091 B1, 2002 ;
Location in patent: Example 71 ;
