2-溴-5-甲基-3-噻吩羧酸合成路线 （共 3 条）
反应条件
bromine; acetic acid T=20°C; 1 h;
参考文献
ELI LILLY AND COMPANY; LEDGARD, Andrew, James
Patent: WO2013/32804 A1, 2013 ;
Location in patent: Page/Page column 7 ;
反应条件
1.1: n-BuLi / dimethyl ether; hexane / 1 h / -70 °C 1.2: 54 percent / dimethyl ether / 0.5 h / -70 °C 2.1: 72 percent / bromine / acetic acid / 3 h / 20 °C View Scheme
参考文献
ELI LILLY AND COMPANY; LEDGARD, Andrew, James
Patent: WO2013/32804 A1, 2013 ;
反应条件
1: sodium hydroxide; water / methanol / 0.75 h / 65 °C 2: acetic acid; bromine / 1 h / 20 °C View Scheme
参考文献
ELI LILLY AND COMPANY; LEDGARD, Andrew, James
Patent: WO2013/32804 A1, 2013 ;
