2-(3-溴-6-甲基-2-吡嗪酮-1(2H)-基)乙酸乙酯合成路线 （共 6 条）
反应条件
in hexane; chloroform
参考文献
3-Dimensional Pharmaceuticals, Inc.
Patent: US2002/52357 A1, 2002 ;
反应条件
disodium hydrogenphosphate; phosphorus oxytribromide in 1,2-dichloro-ethane T=50°C; Bromination; 18 h;
参考文献
Fleitz, Fred J.; Lyle, Terry A.; Zheng, Nan; Armstrong III, Joseph D.; Volante
Synthetic Communications, 2000 , vol. 30, # 17 p. 3171 - 3180
反应条件
1: 97 percent / ethanol / Heating 2: 62 percent / RuCl3; aq. NaBrO3 3: TFAA / 80 °C 4: POBr3; aq. NH3 / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 8 p. 1203 - 1208
反应条件
1: 62 percent / RuCl3; aq. NaBrO3 2: TFAA / 80 °C 3: POBr3; aq. NH3 / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 8 p. 1203 - 1208
反应条件
1: TFAA / 80 °C 2: POBr3; aq. NH3 / Heating View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 8 p. 1203 - 1208
反应条件
1: Et3N / dioxane / 65 - 100 °C
2: aq. LiOH / tetrahydrofuran / 20 °C
View Scheme
参考文献
Fleitz, Fred J.; Lyle, Terry A.; Zheng, Nan; Armstrong III, Joseph D.; Volante
Synthetic Communications, 2000 , vol. 30, # 17 p. 3171 - 3180
