1-苄基-4-苯基-3-吡咯烷甲醇合成路线 （共 8 条）
反应条件
1: With sodium bis(2-methoxyethoxy)aluminium dihydride in toluene T=14 - 30°C; 3 h; Inert atmosphere; 2: With water; sodium hydroxide in toluene
参考文献
ASTELLAS PHARMA INC.
Patent: US2012/22271 A1, 2012 ;
Location in patent: Page/Page column 9 ;
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=20 - 40°C; 2: With sodium hydroxide; water in tetrahydrofuran 0.25 h;
参考文献
Kong, Laval Chan Chun; Moinet, Christophe; Vaillancourt, Louis; Bubenik, Monica
Patent: US2006/14769 A1, 2006 ;
Location in patent: Page/Page column 14 ;
反应条件
lithium aluminium tetrahydride in tetrahydrofuran T=0 - 20°C;
参考文献
Hale, Jeffrey J.; Budhu, Richard J.; Mills, Sander G.; MacCoss, Malcolm; Malkowitz, Lorraine; Siciliano, Salvatore; Gould, Sandra L.; DeMartino, Julie A.; Springer, Martin S.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 11 p. 1437 - 1440
反应条件
1: TFA / CH2Cl2 / 0 - 20 °C 2: 69 percent / LiAlH4 / tetrahydrofuran / 0 - 20 °C View Scheme
参考文献
Hale, Jeffrey J.; Budhu, Richard J.; Mills, Sander G.; MacCoss, Malcolm; Malkowitz, Lorraine; Siciliano, Salvatore; Gould, Sandra L.; DeMartino, Julie A.; Springer, Martin S.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 11 p. 1437 - 1440
反应条件
1: TFA / CH2Cl2 / 0 - 20 °C 2: 69 percent / LiAlH4 / tetrahydrofuran / 0 - 20 °C View Scheme
参考文献
Hale, Jeffrey J.; Budhu, Richard J.; Mills, Sander G.; MacCoss, Malcolm; Malkowitz, Lorraine; Siciliano, Salvatore; Gould, Sandra L.; DeMartino, Julie A.; Springer, Martin S.
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 11 p. 1437 - 1440
反应条件
1.1: phenol / ethanol / 8 h / 81 - 83 °C / Inert atmosphere 1.2: 3 h / 6 - 23 °C / Inert atmosphere 2.1: sodium hexamethyldisilazane / toluene / 0.25 h / -30 - -25 °C 2.2: 7 h / Reflux 2.3: 11 °C / pH 4 3.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 3 h / 14 - 30 °C / Inert atmosphere View Scheme
参考文献
ASTELLAS PHARMA INC.
Patent: US2012/22271 A1, 2012 ;
反应条件
1.1: phenol / ethanol / 8 h / 81 - 83 °C / Inert atmosphere 1.2: 3 h / 6 - 23 °C / Inert atmosphere 2.1: sodium hexamethyldisilazane / toluene / 0.25 h / -30 - -25 °C 2.2: 7 h / Reflux 2.3: 11 °C / pH 4 3.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 3 h / 14 - 30 °C / Inert atmosphere View Scheme
参考文献
ASTELLAS PHARMA INC.
Patent: US2012/22271 A1, 2012 ;
反应条件
1: With ammonium formate; palladium dihydroxide in ehanol
1.5 h; Heating / reflux;
2: With ammonia in methanol; ethanol
0.5 h; Heating / reflux;
参考文献
Kong, Laval Chan Chun; Moinet, Christophe; Vaillancourt, Louis; Bubenik, Monica
Patent: US2006/14769 A1, 2006 ;
Location in patent: Page/Page column 14 ;
