5-氨磺酰基-2-甲氧基苯甲酸合成路线 （共 8 条）
反应条件
sodium hydroxide in methanol
参考文献
Institute of Medicinal Molecular Design, Inc.
Patent: EP1510207 A1, 2005 ;
Location in patent: Page/Page column 134 ;
EP 1510207 A1
Title/Abstract Full Text Show Details
Institute of Medicinal Molecular Design, Inc.
Patent: EP1510210 A1, 2005 ;
Location in patent: Page/Page column 134 ;
反应条件
ammonia in tetrahydrofuran 0.5 h; Ambient temperature;
参考文献
Harrold, Marc W.; Wallace, Raye Ann; Farooqui, Tahira; Wallace, Lane J.; Uretsky, Norman; Miller, Duane D.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 874 - 880
反应条件
1: 84.9 percent / chlorosulfuric acid / 0.67 h / 60 - 70 °C 2: 94.6 percent / NH3 / tetrahydrofuran / 0.5 h / Ambient temperature View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 32, # 4 p. 874 - 880
参考文献
Iusco; Boido; Sparatore
Farmaco, 1996 , vol. 51, # 3 p. 159 - 174
反应条件
triethylamine in acetonitrile
参考文献
Ogura; Haruo
Patent: US4341707 A1, 1982 ;
反应条件
ammonium hydroxide; triethylamine in tetrahydrofuran; hydrogenchloride
参考文献
Fujisawa Pharmaceutical Co., Ltd.
Patent: US4242507 A1, 1980 ;
反应条件
chloroformic acid ethyl ester; triethylamine
1.) acetone, 0 deg C, 0.5 h, 2.) 0 deg C, 0.5 h then r.t., 2.5 h; Yield given. Multistep reaction;
参考文献
Harrold, Marc W.; Wallace, Raye Ann; Farooqui, Tahira; Wallace, Lane J.; Uretsky, Norman; Miller, Duane D.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 874 - 880
反应条件
pyridine; thionyl chloride
Heating;
参考文献
Brennan; Imondi; Westmoreland; Williamson
Journal of Pharmaceutical Sciences, 1982 , vol. 71, # 11 p. 1199 - 1203
