1.1: 79 percent / TBDMS-OBt / tetrahydrofuran / 0.5 h / 20 °C 2.1: 85 percent / 4-aminomethylpiperidine / CH2Cl2 / 0.5 h 3.1: 72 percent / TBDMS-OBt / tetrahydrofuran / 0.5 h / 20 °C 4.1: aq. HCOOH / Pd/C / methanol / 3 h / 20 °C 4.2: 80 percent / aq. NaHCO3 / 0.33 h View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '605268', constants.ctx, '0')">diethylamine</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1730800', constants.ctx, '0')">dichloromethane</a> <br />T=20&deg;C;&nbsp;0.5&nbsp;h;&nbsp;&nbsp;Inert atmosphere;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 86 percent / 4-aminomethylpiperidine / CH₂Cl₂ / 0.5 h<br />2: 70 percent / TBDMS-OBt / tetrahydrofuran / 0.5 h / 20 &deg;C<br />3: 81 percent / 4-aminomethylpiperidine / CH₂Cl₂ / 0.5 h<br /> <br /> &nbsp;