N-alpha-Cbz-L-赖氨酸合成路线 （共 34 条）
反应条件
acetic acid; cadmium in N,N-dimethyl-formamide 12 h; Yield given;
参考文献
Tetrahedron Letters, , vol. 23, # 2 p. 249 - 252
反应条件
water T=21°C; pH dependence of the rate constant and catalytic effect of amino acid, E(act.), ΔS(excit.); KineticsThermodynamic dataMechanism;
参考文献
Gazzetta Chimica Italiana, , vol. 112, # 7/8 p. 307 - 318
反应条件
potassium carbonate in 1,4-dioxane 1 h;
参考文献
Xue; Voss; Nelson; Duan; Cherney; Jacobson; He; Roderick; Chen; Corbett; Wang; Meyer; Kennedy; Degrado; Hardman; Teleha; Jaffee; Liu; Copeland; Covington; Christ; Trzaskos; Newton; Magolda; Wexler; Decicco
Journal of Medicinal Chemistry, 2001 , vol. 44, # 16 p. 2636 - 2660
反应条件
sodium hydroxide in 1,4-dioxane; sodium hydrogencarbonate
参考文献
Italfarmaco S.p.A.
Patent: US6057295 A1, 2000 ;
反应条件
pyridine T=20°C; 24 h;
参考文献
Heltweg, Birgit; Dequiedt, Franck; Marshall, Brett L.; Brauch, Carsten; Yoshida, Minoru; Nishino, Norikazu; Verdin, Eric; Jung, Manfred
Journal of Medicinal Chemistry, 2004 , vol. 47, # 21 p. 5235 - 5243
反应条件
sodium cyanoborohydride in water T=100°C; 4 h;
参考文献
Walton, Donald J.; Ison, Edward R.; Szarek, Walter A.
Carbohydrate Research, 1984 , vol. 128, p. 37 - 50
反应条件
hydrogen; hydroxyapatite-bound Pd in methanol T=40°C; 3 h;
参考文献
Murata, Makoto; Hara, Takayoshi; Mori, Kohsuke; Ooe, Masahiko; Mizugaki, Tomoo; Ebitani, Kohki; Kaneda, Kiyotomi
Tetrahedron Letters, 2003 , vol. 44, # 27 p. 4981 - 4984
反应条件
1: triethylamine, ethyl chloroformate / CHCl3 / 1.) -5 degC, 30 min., 2.) heating to bp. 2: 40percent HBr / acetic acid View Scheme
参考文献
Canadian Journal of Chemistry, , vol. 60, p. 3081 - 3084
反应条件
1: Nα-(benzyloxycarbonyl)-L-lysine oxidase from Rhodococcus sp. AIU Z-35-1; 1,5-dimethyl-2-phenyl-4-amino-3-pyrazolone; N-ethyl-N-(2-hydroxy-3-sulfonatopropyl)-3-methylaniline sodium salt / 30 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction 2: Nα-(benzyloxycarbonyl)aminoadipic acid-δ-semialdehyde dehydrogenase from Rhodococcus sp. AIU Z-35-1; Reduced nicotinamide-adenine dinucleotide / 30 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction View Scheme
参考文献
Isobe, Kimiyasu; Fukuda, Nahoko; Nagasawa, Shouko; Saitou, Kaoru
Chemistry and Biodiversity, 2010 , vol. 7, # 6 p. 1549 - 1554
反应条件
1: 866 g / tetramethylguanidine / dimethylsulfoxide / 4.5 h / 50 °C 2: 98 percent / H2 / Pd/C / methanol; H2O / 20 °C / 2327.2 - 2844.3 Torr View Scheme
参考文献
Zervas,L.; Hamalidis,C.
Journal of the American Chemical Society, 1965 , vol. 87, p. 99 - 104
