4-三氟甲基-6-苯基吡啶-2-酮合成路线 （共 3 条）
反应条件
1.1: diisopropylamine; n-butyllithium / tetrahydrofuran; hexane / 0.08 h / -78 °C 1.2: 0.5 h / -78 °C 1.3: 16 h / |Reflux 2.1: triethylamine; titanium tetrachloride / dichloromethane / 16 h / 0 - 20 °C 3.1: N-ethyl-N,N-diisopropylamine; pivaloyl chloride / tetrahydrofuran / 0.17 h / 0 °C 3.2: 20 h / 20 °C / |Reflux 4.1: tetra(n-butyl)ammonium hydroxide / ethanol; water / 0.25 h / 20 °C View Scheme
参考文献
Stark, Daniel G.; Morrill, Louis C.; Yeh, Pei-Pei; Slawin, Alexandra M. Z.; O'Riordan, Timothy J. C.; Smith, Andrew D.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 44 p. 11642 - 11646
Angew. Chem., 2013 , vol. 125, # 44 p. 11856 - 11860,5
反应条件
1.1: triethylamine; titanium tetrachloride / dichloromethane / 16 h / 0 - 20 °C 2.1: N-ethyl-N,N-diisopropylamine; pivaloyl chloride / tetrahydrofuran / 0.17 h / 0 °C 2.2: 20 h / 20 °C / |Reflux 3.1: tetra(n-butyl)ammonium hydroxide / ethanol; water / 0.25 h / 20 °C View Scheme
参考文献
Stark, Daniel G.; Morrill, Louis C.; Yeh, Pei-Pei; Slawin, Alexandra M. Z.; O'Riordan, Timothy J. C.; Smith, Andrew D.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 44 p. 11642 - 11646
Angew. Chem., 2013 , vol. 125, # 44 p. 11856 - 11860,5
反应条件
1.1: triethylamine; titanium tetrachloride / dichloromethane / 16 h / 0 - 20 °C 2.1: N-ethyl-N,N-diisopropylamine; pivaloyl chloride / tetrahydrofuran / 0.17 h / 0 °C 2.2: 20 h / 20 °C / |Reflux 3.1: tetra(n-butyl)ammonium hydroxide / ethanol; water / 0.25 h / 20 °C View Scheme
参考文献
Stark, Daniel G.; Morrill, Louis C.; Yeh, Pei-Pei; Slawin, Alexandra M. Z.; O'Riordan, Timothy J. C.; Smith, Andrew D.
Angewandte Chemie - International Edition, 2013 , vol. 52, # 44 p. 11642 - 11646
Angew. Chem., 2013 , vol. 125, # 44 p. 11856 - 11860,5
