(3-甲基哌啶-3-基)甲醇合成路线 (共 2 条)
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=18 - 25°C; 15 h; 2: With sodium hydroxide; ammonia; water; Sodium potassium tartrate in tetrahydrofuran T=-5°C; 0.5 h;
参考文献
EP1015431 B1, ;
Page/Page column 28 ;
EP 1015431 B1
反应条件
triethylamine in dichloromethane
T=20°C; Inert atmosphere;
参考文献
GLAXOSMITHKLINE LLC; AMANS, Dominique; BAMBOROUGH, Paul; BIT, Rino, Antonio; BROWN, John, Alexander; CAMPBELL, Matthew; LINDON, Matthew, John; SHIPLEY, Tracy, Jane; THEODOULOU, Natalie, Hope; WELLAWAY, Christopher, Roland; WESTAWAY, Susan, Marie
Patent: WO2014/78257 A1, 2014 ;
Location in patent: Page/Page column 132 ;