2-(羟基甲基)噻唑-4-甲酸合成路线 （共 4 条）
反应条件
potassium carbonate in methanol; water 4.5 h; Heating;
参考文献
Journal of Medicinal Chemistry, , vol. 45, # 18 p. 3878 - 3890
反应条件
1: With methanol; water; sodium hydroxide in tetrahydrofuran 72 h; 2: With hydrogenchloride in tetrahydrofuran; water
参考文献
WO2009/144494 A1, ;
Page/Page column 109 ;
WO 2009/144494 A1
反应条件
1: 2-(hydroxymethyl)-1,3-thiazole-4-carboxylic acid With sodium hydride in N,N-dimethyl-formamide; mineral oil 0.333333 h; 2: methyl iodide in N,N-dimethyl-formamide 2 h;
参考文献
ASTRAZENECA AB; ASTRAZENECA UK LIMITED
Patent: WO2009/144494 A1, 2009 ;
Location in patent: Page/Page column 117 ;
WO 2009/144494 A1
反应条件
sulfuric acid
5 h; Heating / reflux;
参考文献
Dhar, T. G. Murali; Potin, Dominique; Maillet, Magali Jeannine Blandine; Launay, Michele; Nicolai, Eric Antoine; Iwanowicz, Edwin J.
Patent: US2004/9998 A1, 2004 ;
Location in patent: Page/Page column 39-40 ;
