(S)-(-)-1-苯基-1-丁醇合成路线 （共 63 条）
反应条件
n-butyllithium; (2S,2'S)-2-hydroxymethyl-1-lt;(1-methylpyrrolidine-2-yl)methylgt;pyrrolidine in toluene T=-110°C; 1 h; Yield given. Yields of byproduct given;
参考文献
Tetrahedron, , vol. 37, # 23 p. 4111 - 4119
反应条件
1,) chiral catalyst 2.) diethyl ether, -120 deg C; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Journal of the American Chemical Society, , vol. 103, # 15 p. 4585 - 4586
反应条件
1: N,N-dimethylaminopyridine (DMAP), Et3N / CH2Cl2 / 3 h / Ambient temperature 2: H2, quinoline / Pd (5percent on BaSO4) / 1.5 h 4: 1.) boron trifluoride 2.) aq. sodium hydrogen carbonate / 1.) AcOH, CH2Cl2, 20 deg C, 1.5 h 2.) 15 min 5: Et3N, m-chloroperbenzoic acid / diethyl ether / 20 h / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 24 p. 3331 - 3350
反应条件
1: H2, quinoline / Pd (5percent on BaSO4) / 1.5 h 3: 1.) boron trifluoride 2.) aq. sodium hydrogen carbonate / 1.) AcOH, CH2Cl2, 20 deg C, 1.5 h 2.) 15 min 4: Et3N, m-chloroperbenzoic acid / diethyl ether / 20 h / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 24 p. 3331 - 3350
反应条件
2: N,N-dimethylaminopyridine (DMAP), Et3N / CH2Cl2 / 3 h / Ambient temperature 3: H2, quinoline / Pd (5percent on BaSO4) / 1.5 h 5: 1.) boron trifluoride 2.) aq. sodium hydrogen carbonate / 1.) AcOH, CH2Cl2, 20 deg C, 1.5 h 2.) 15 min 6: Et3N, m-chloroperbenzoic acid / diethyl ether / 20 h / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 24 p. 3331 - 3350
反应条件
tetra-n-butylammonium tetrafluoroborate; (1R,2S)-(-)-N,N-dimethylephedrinium tetrafluoroborate in water; N,N-dimethyl-formamide Electrolysis;
参考文献
Yadav, Ashok K.; Singh, Arpita
Bulletin of the Chemical Society of Japan, 2002 , vol. 75, # 3 p. 587 - 588
参考文献
Tamai, Yasufumi; Koike, Shinji; Ogura, Atsuhiko; Miyano, Sotaro
Journal of the Chemical Society, Chemical Communications, 1991 , # 12 p. 799 - 800
反应条件
Yield given. Multistep reaction;
参考文献
Angewandte Chemie, , vol. 103, # 8 p. 991 - 992
反应条件
50 U aminoacylase E.C. 3.5.1.14 in hexane Acetylation; 168 h;
参考文献
Bakker; Spruijt; Van Rantwijk; Sheldon
Tetrahedron Asymmetry, 2000 , vol. 11, # 8 p. 1801 - 1808
反应条件
1: triphenyl boroxine With diethylzinc in hexane T=60°C; 10 h; Sealed vesselInert atmosphere; 2: With diethylzinc; (Ra)-N-[(1S,2R)-1,2-diphenyl-2-hydroxyethyl]-3,5-dihydro-4H-dinaphtho[2,1-c:1',2'-e]-azepine in hexane; toluene T=20°C; 0.5 h; Inert atmosphere; 3: butyraldehyde optical yield given as percent eeenantioselective reactionFurther stages;
参考文献
Chirality, , vol. 22, # 1 p. 159 - 164
