(S)-(-)-1-苯基-1-丁醇合成路线 （共 63 条）
反应条件
2: 1.) boron trifluoride 2.) aq. sodium hydrogen carbonate / 1.) AcOH, CH2Cl2, 20 deg C, 1.5 h 2.) 15 min 3: Et3N, m-chloroperbenzoic acid / diethyl ether / 20 h / Ambient temperature View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 24 p. 3331 - 3350
反应条件
1: 89 percent / imidazole / dimethylformamide 2: 86 percent / LiAlH4 / diethyl ether 3: 52 percent / N,N-dimethylaminopyridine, pyridine 4: 91 percent / LiAlH4 / diethyl ether 5: 70 percent / 66percent aq. AcOH View Scheme
参考文献
Journal of the Chemical Society, Chemical Communications, , # 12 p. 799 - 800
反应条件
1: 52 percent / N,N-dimethylaminopyridine, pyridine 2: 91 percent / LiAlH4 / diethyl ether 3: 70 percent / 66percent aq. AcOH View Scheme
参考文献
Journal of the Chemical Society, Chemical Communications, , # 12 p. 799 - 800
反应条件
1: 86 percent / LiAlH4 / diethyl ether 2: 52 percent / N,N-dimethylaminopyridine, pyridine 3: 91 percent / LiAlH4 / diethyl ether 4: 70 percent / 66percent aq. AcOH View Scheme
参考文献
Journal of the Chemical Society, Chemical Communications, , # 12 p. 799 - 800
反应条件
1: 91 percent / LiAlH4 / diethyl ether 2: 70 percent / 66percent aq. AcOH View Scheme
参考文献
Journal of the Chemical Society, Chemical Communications, , # 12 p. 799 - 800
反应条件
molecular sieve; lipase B from Candida antarctica in 1,4-dioxane T=30°C; 163 h; Title compound not separated from byproducts;
参考文献
Tetrahedron Asymmetry, , vol. 12, # 21 p. 3047 - 3052
反应条件
4 A molecular sieve; lipase B (Candida antarctica, Novozym 435); 1-phenyl-2-methylethylamine in 1,4-dioxane T=30°C; 163 h; Enzymatic reaction; Product distribution; Further Variations:ReagentsSolventsratio;
参考文献
Advanced Synthesis and Catalysis, , vol. 343, # 6-7 p. 646 - 654
反应条件
Lipase Amano AK T=20°C; pH=7; 62 h; aq. phosphate bufferEnzymatic reaction; optical yield given as percent ee;
参考文献
Journal of Molecular Catalysis B: Enzymatic, , vol. 72, # 3-4 p. 270 - 275
反应条件
1: triethylamine / dichloromethane / 0 °C 2: Lipase Amano AK / 62 h / 20 °C / pH 7 / aq. phosphate buffer; Enzymatic reaction View Scheme
参考文献
Journal of Molecular Catalysis B: Enzymatic, , vol. 72, # 3-4 p. 270 - 275
参考文献
Tetrahedron Letters, , vol. 24, # 47 p. 5257 - 5260
