(S)-(-)-1-苯基-1-丁醇合成路线 （共 63 条）
反应条件
magnesium 1.) ether, reflux, 2.) r.t., overnight; Yield given. Multistep reaction. Title compound not separated from byproducts;
参考文献
Tetrahedron, , vol. 47, # 36 p. 7645 - 7662
反应条件
1: strychnine 2: platinum / Hydrogenation 3: LiAlH4 View Scheme
参考文献
Journal of the Chemical Society, , p. 145
反应条件
Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 45, # 16 p. 3352 - 3355
反应条件
potassium hydroxide; hydrogen 2) MeOH, 1 atm., 3 d; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Chemische Berichte, , vol. 119, # 6 p. 2013 - 2024
反应条件
1,4-dioxane; titanium(IV) isopropylate; bis{(4R,5R)-2,2-dimethyl-α,α,α',α'-tetraphenyl-1,3-dioxolane-4,5-dimethanolato-O,O'}titanium(IV); zinc(II) chloride 1a.) Et2O, r.t., 2 h, 1b.) 45 min, 2a.) -78 deg C, 1 h, 2b) -30 deg C; Yield given. Multistep reaction. Yields of byproduct given. Title compound not separated from byproducts;
参考文献
Tetrahedron, , vol. 48, # 27 p. 5719 - 5730
反应条件
1: diphenylphosphoryl azide; DBU / toluene 2: H2 / Pd-C / ethyl acetate; ethanol / 2068.59 Torr View Scheme
参考文献
Mori, Yutaka; Ogawa, Yasuyuki; Mochizuki, Akiyoshi; Nakamura, Yuji; Fujimoto, Teppei; Sugita, Chie; Miyazaki, Shojiro; Tamaki, Kazuhiko; Nagayama, Takahiro; Nagai, Yoko; Inoue, Shin-Ichi; Chiba, Katsuyoshi; Nishi, Takahide
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 18 p. 5907 - 5922
反应条件
lyophilised cells of Escherichia coli overexpressing the solvent-tolerant alcohol dehydrogenase from Rhodococcus ruber DSM44541 in aq. buffer T=30°C; pH=7.5; 24 h; Resolution of racemateEnzymatic reaction;
参考文献
Paul, Caroline E.; Lavandera, Ivan; Gotor-Fernandez, Vicente; Kroutil, Wolfgang; Gotor, Vicente
ChemCatChem, 2013 , vol. 5, # 12 p. 3875 - 3881
反应条件
[Ir(η5-C5Me5)(C6H4-2-CH2NHCH3)(NCCH3)](PF6); potassium tert-butylate in toluene T=20°C; 12 h; Inert atmosphere;
参考文献
Jerphagnon, Thomas; Gayet, Arnaud J.A.; Berthiol, Florian; Ritleng, Vincent; Mrsic, Natasa; Meetsma, Auke; Pfeffer, Michel; Minnaard, Adriaan J.; Feringa, Ben L.; De Vries, Johannes G.
Chemistry - A European Journal, 2009 , vol. 15, # 46 p. 12780 - 12790
反应条件
[Ir(η5-C5Me5)(C6H4-2-CH2NHCH3)(NCCH3)](PF6); potassium tert-butylate in toluene T=20°C; 12 h; Inert atmosphere;
参考文献
Jerphagnon, Thomas; Gayet, Arnaud J.A.; Berthiol, Florian; Ritleng, Vincent; Mrsic, Natasa; Meetsma, Auke; Pfeffer, Michel; Minnaard, Adriaan J.; Feringa, Ben L.; De Vries, Johannes G.
Chemistry - A European Journal, 2009 , vol. 15, # 46 p. 12780 - 12790
反应条件
sodium periodate; lithium aluminium tetrahydride; RuO4 1.) CH2Cl2/H2O, 2.) Et2O; Multistep reaction;
参考文献
Furukawa, Jun; Iwasaki, Shigeo; Okuda, Shigenobu
Tetrahedron Letters, 1983 , vol. 24, # 47 p. 5257 - 5260
