(R,S)-Boc-1,3-二氢-2H-异吲哚羧酸合成路线 （共 10 条）
反应条件
lithium hydroxide; water in methanol T=20 - 45°C; 18 h;
参考文献
US2004/82590 A1, ;
Page/Page column 93-94 ;
US 20040082590 A1
反应条件
1: With water; sodium hydroxide T=60°C; 3 h; 2: With potassium hydrogensulfate in water T=20°C;
参考文献
Organic Letters, , vol. 14, # 7 p. 1696 - 1699
反应条件
1: With cesium fluoride in N,N-dimethyl-formamide T=120°C; P=7500.75 Torr; 3 h; Autoclave; 2: With hydrogenchloride in diethyl ether; water; N,N-dimethyl-formamide T=0°C; pH=2; Inert atmosphere;
参考文献
Journal of Organic Chemistry, , vol. 77, # 5 p. 2159 - 2168
反应条件
1.1: pyridinium p-toluenesulfonate / 2 h / 20 °C 2.1: boron trifluoride diethyl etherate / dichloromethane / 1 h / -78 °C / Inert atmosphere 3.1: water; sodium hydroxide / 3 h / 60 °C 3.2: 20 °C View Scheme
参考文献
Organic Letters, , vol. 14, # 7 p. 1696 - 1699
反应条件
1.1: boron trifluoride diethyl etherate / dichloromethane / 1 h / -78 °C / Inert atmosphere 2.1: water; sodium hydroxide / 3 h / 60 °C 2.2: 20 °C View Scheme
参考文献
Organic Letters, , vol. 14, # 7 p. 1696 - 1699
参考文献
Lin, Linus S.; Shah, Shrenik K.; Chang, Linda L.; Hagmann, William K.; Mumford, Richard A.
Patent: US2002/193399 A1, 2002 ;
参考文献
Lin, Linus S.; Shah, Shrenik K.; Chang, Linda L.; Hagmann, William K.; Mumford, Richard A.
Patent: US2002/193399 A1, 2002 ;
反应条件
hydrogenchloride; water; acetic acid
72 h; Reflux;
参考文献
Moran-Ramallal, Roberto; Gotor-Fernandez, Vicente; Laborda, Pedro; Sayago, Francisco J.; Cativiela, Carlos; Gotor, Vicente
Organic Letters, 2012 , vol. 14, # 7 p. 1696 - 1699
反应条件
potassium carbonate in N,N-dimethyl-formamide
T=20°C; 12 h;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/53319 A1, 2008 ;
Location in patent: Page/Page column 63 ;
反应条件
acetic acid in methanol; toluene
T=20°C; 2 h;
参考文献
Luckhurst, Christopher A.; Stein, Linda A.; Furber, Mark; Webb, Nicola; Ratcliffe, Marianne J.; Allenby, Gary; Botterell, Sara; Tomlinson, Wendy; Martin, Barrie; Walding, Andrew
Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 1 p. 492 - 496
