Boc-(2S,4S)-4-amino-1-Fmoc-pyrrolidine-2-carboxylic acid合成路线 （共 6 条）
反应条件
1: methyl (2S,4S)-4-[(tert-butoxycarbonyl)amino]-2-pyrrolidinecarboxylate With sodium hydroxide in methanol 2: (9H-Fluoren-9-yl)-methyl chloroformate With sodium carbonate in 1,4-dioxane; water Further stages.;
参考文献
Umashankara; Babu, I Ramesh; Ganesh, Krishna N
Chemical communications (Cambridge, England), 2003 , # 20 p. 2606 - 2607
反应条件
1: H2 / Pd/C / ethanol / 12 h / 20 °C 2: 1.18 g / Et3N / H2O; tetrahydrofuran; acetonitrile / 2 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 9 p. 3280 - 3289
反应条件
1: 96 percent / Et3N / tetrahydrofuran / 7.5 h / 20 °C 2: H2 / Pd/C / ethanol / 12 h / 20 °C 3: 1.18 g / Et3N / H2O; tetrahydrofuran; acetonitrile / 2 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 9 p. 3280 - 3289
反应条件
1: 96 percent / Et3N / tetrahydrofuran / 7.5 h / 20 °C 2: H2 / Pd/C / ethanol / 12 h / 20 °C 3: 1.18 g / Et3N / H2O; tetrahydrofuran; acetonitrile / 2 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 48, # 9 p. 3280 - 3289
反应条件
triethylamine in tetrahydrofuran; water; acetonitrile T=20°C; 2 h;
参考文献
Tamamura, Hirokazu; Araki, Takanobu; Ueda, Satoshi; Wang, Zixuan; Oishi, Shinya; Esaka, Ai; Trent, John O.; Nakashima, Hideki; Yamamoto, Naoki; Peiper, Stephen C.; Otaka, Akira; Fujii, Nobutaka
Journal of Medicinal Chemistry, 2005 , vol. 48, # 9 p. 3280 - 3289
反应条件
sodium carbonate in 1,4-dioxane; water T=0°C; Substitution;
参考文献
Zhang, Zhenyu; Aerschot, Arthur Van; Hendrix, Chris; Busson, Roger; David, Frank; Sandra, Pat; Herdewijn, Piet
Tetrahedron, 2000 , vol. 56, # 16 p. 2513 - 2522
