1: in diethyl ether; dichloromethane T=-48°C; Grignard reaction; 2: With hydrogenchloride in 1,4-dioxane; methanol T=20°C; Substitution; 0.5 h; Solvolysis; Title compound not separated from byproducts;

1: in diethyl ether; dichloromethane T=-48°C; Grignard reaction; 2: With hydrogenchloride in 1,4-dioxane; methanol T=20°C; Substitution; 0.5 h; Solvolysis; Title compound not separated from byproducts;

1.1: Mg; I2 / diethyl ether / 1 h / 20 °C 1.2: diethyl ether / 12 h / -48 °C 2.1: aq. TFA / 0.5 h 2.2: Et3SiH / 24 h View Scheme

1: in diethyl ether; dichloromethane T=-48°C; Grignard reaction; 2: With hydrogenchloride in 1,4-dioxane; methanol T=20°C; Substitution; 0.5 h; Solvolysis; Title compound not separated from byproducts;