(R)-(+)-1-苯基-1-丁醇合成路线 （共 41 条）
反应条件
(2-((2,4-dimethyl-5-phenylimidazo[1,5-b]pyridazin-7-yl)amido)-4-methylpentan-1-ol)(1,5-cyclooctadiene)iridium(I); potassium tert-butylate; hydrogen; acetone in tetrahydrofuran T=20°C; P=15.0015 Torr; 48 h; Autoclave; optical yield given as percent eeenantioselective reaction;
参考文献
Irrgang, Torsten; Friedrich, Denise; Kempe, Rhett
Angewandte Chemie - International Edition, 2011 , vol. 50, # 9 p. 2183 - 2186
反应条件
D-glucose; D-glucose dehydrogenase; Sporobolomyces salmonicolor carbonyl reductase; NADPH in phosphate buffer; dimethyl sulfoxide T=20°C; pH=6.5 - 6.6; Title compound not separated from byproducts;
参考文献
Zhu, Dunming; Hua, Ling
Journal of Organic Chemistry, 2006 , vol. 71, # 25 p. 9484 - 9486
反应条件
BF3·2HOAc; triethylamine; 3-chloro-benzenecarboperoxoic acid Title compound not separated from byproducts;
参考文献
Journal of the Chemical Society, Chemical Communications, , # 18 p. 1456 - 1457
反应条件
1: dimethylaluminium chloride / CH2Cl2; hexane / 24 h / 20 °C 2: 93 percent / various solvent(s) / 12 h / 20 °C 3: Raney nickel / ethanol / 24 h / 20 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 122, # 9 p. 1927 - 1936
反应条件
sodium isopropanolate; acetone; [RuCl2(PPh3)(ferrocenyloxazolinylphosphine)] in isopropyl alcohol T=50°C; 0.5 h;
参考文献
Journal of Organic Chemistry, , vol. 68, # 15 p. 5875 - 5880
反应条件
titanium(IV) isopropylate in diethyl ether; dichloromethane T=0°C; 1 h; Title compound not separated from byproducts.;
参考文献
Muramatsu, Yusuke; Harada, Toshiro
Angewandte Chemie - International Edition, 2008 , vol. 47, # 6 p. 1088 - 1090
反应条件
(1S,2R)-(+)-N,N-dimethylephedrinium bis(trifluoromethanesulfon)imidate in dichloromethane T=120°C;
参考文献
Analytical Chemistry, , vol. 76, # 22 p. 6819 - 6822
反应条件
1: n-propyl-magnesium chloride With titanium(IV) isopropylate in dichloromethane T=-78°C; 0.166667 h; Inert atmosphere; 2: benzaldehyde With (R)-3-(3,5-diphenylphenyl)-2,2'-dihydroxy-1,1'-binaphthyl in diethyl ether; dichloromethane T=0°C; 3 h; Inert atmosphere; 3: With hydrogenchloride; water in diethyl ether; dichloromethane T=0°C; Inert atmosphere; optical yield given as percent eeenantioselective reaction;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 83, # 1 p. 19 - 32
反应条件
EL-03 lipase T=30°C; 101 h; Enzymatic reaction; optical yield given as percent eeenantioselective reaction;
参考文献
Tetrahedron Asymmetry, , vol. 23, # 8 p. 583 - 586
反应条件
Pseudomonas monteilii TA-5 in methanol T=30°C; pH=7; 1 h; aq. phosphate buffer; optical yield given as percent eeenantioselective reaction;
参考文献
Advanced Synthesis and Catalysis, , vol. 351, # 13 p. 2107 - 2112
