N-甲氧基-N,6-二甲基烟酰胺合成路线 （共 12 条）
反应条件
4-methyl-morpholine; 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholin-4-ium chloride in tetrahydrofuran; methanol T=20°C; 3 h;
参考文献
DAIICHI SANKYO COMPANY, LIMITED
Patent: US2011/112103 A1, 2011 ;
Location in patent: Page/Page column 66 ;
反应条件
1: O,N-dimethyl-hydroxylamine hydrochloride With dimethylaluminum chloride in hexane; dichloromethane T=0°C; 1 h; Inert atmosphere; 2: methyl 2-methyl-5-pyridinecarboxylate in hexane; dichloromethane T=20°C;
参考文献
Amishiro, Nobuyoshi; Fukuda, Yuichi; Kinpara, Keisuke; Mie, Motoya; Tagaya, Hisashi; Takahashi, Takeshi
Patent: US2011/237584 A1, 2011 ;
Location in patent: Page/Page column 133-134 ;
US 20110237584 A1
反应条件
O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine in N,N-dimethyl-formamide T=20°C; 12 h;
参考文献
PFIZER JAPAN INC.; PFIZER INC.
Patent: WO2008/32204 A1, 2008 ;
Location in patent: Page/Page column 37-38 ;
WO 2008/032204 A1
反应条件
1: 6-methyl-3-pyridine-carboxylic acid With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in DMF (N,N-dimethyl-formamide) T=20°C; 0.5 h; 2: N,N-dimethyl-formamide dimethyl acetal in DMF (N,N-dimethyl-formamide) T=20°C;
参考文献
J. URIACH Y COMPANIA S.A.
Patent: WO2004/76450 A1, 2004 ;
Location in patent: Page 42-43 ;
WO 2004/076450 A1
反应条件
isopropylmagnesium chloride in tetrahydrofuran T=-10 - 5°C; 2.5 h;
参考文献
Merck and Co., Inc.
Patent: US6369275 B1, 2002 ;
Location in patent: Page column 14-15 ;
反应条件
triethylamine in dichloromethane Substitution;
参考文献
Piotrowski, David W.
Synlett, 1999 , # 7 p. 1091 - 1093
反应条件
1: With diisobutylaluminium hydride in hexane; dichloromethane T=-10°C; 0.166667 h; Inert atmosphere; 2: With water in hexane; dichloromethane T=20°C; 1 h;
参考文献
Amishiro, Nobuyoshi; Fukuda, Yuichi; Kinpara, Keisuke; Mie, Motoya; Tagaya, Hisashi; Takahashi, Takeshi
Patent: US2011/237584 A1, 2011 ;
Location in patent: Page/Page column 134 ;
US 20110237584 A1
反应条件
diisobutylaluminium hydride in toluene T=-20 - -5°C; 0.5 h;
参考文献
Davies; Marcoux; Corley; Journet; Cai; Palucki; Wu; Larsen; Rossen; Pye; DiMichele; Dormer; Reider
Journal of Organic Chemistry, 2000 , vol. 65, # 25 p. 8415 - 8420
反应条件
in tetrahydrofuran; hexane T=0 - 20°C; 16 h;
参考文献
WO2008/32204 A1, ;
Page/Page column 38 ;
WO 2008/032204 A1
反应条件
in tetrahydrofuran Substitution;
参考文献
Synlett, , # 7 p. 1091 - 1093
