Ethanone, 1-(6-methyl-3-pyridinyl)-2-[4-(methylthio)phenyl]-合成路线 （共 3 条）
反应条件
1.1: tBuOK / tetrahydrofuran / 20 °C 1.2: AcOH; TFA / 20 °C 1.3: 74 percent / aq. NH3 / 6 h / Heating 2.1: 84 percent / m-CPBA / CH2Cl2; H2O / 0.67 h / -20 °C View Scheme
参考文献
Majo, Vattoly J.; Prabhakaran, Jaya; Simpson, Norman R.; Van Heertum, Ronald L.; Mann, J. John; Kumar, J. S. Dileep
Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 19 p. 4268 - 4271
反应条件
1: With methanesulfonic acid; acetic acid T=5 - 10°C; 2: With dihydrogen peroxide T=5 - 25°C; 6 h;
参考文献
Castellin, Andrea; Stabile, Paolo; Fontana, Francesco; Lucchi, Ottorino De; Caporale, Andrea; Tartaggia, Stefano
Patent: US2012/232281 A1, 2012 ;
Location in patent: Page/Page column 7 ;
反应条件
1: 89 percent / sodium tungstate; aq. H2O2 / aq. H2SO4; methanol / 55 °C 2: t-BuOK / tetrahydrofuran / 0.75 h / 20 °C 3: AcOH; TFA / tetrahydrofuran / 0.75 h / 25 - 30 °C 4: 8.42 g / aq. NH4OH / tetrahydrofuran / 3 h / Heating View Scheme
参考文献
Davies; Marcoux; Corley; Journet; Cai; Palucki; Wu; Larsen; Rossen; Pye; DiMichele; Dormer; Reider
Journal of Organic Chemistry, 2000 , vol. 65, # 25 p. 8415 - 8420
