2-(4-甲磺酰基苯基)-1-(6-甲基吡啶-3-基)-乙酮合成路线 （共 25 条）
反应条件
1: With methanesulfonic acid; acetic acid T=5 - 10°C; 2: With dihydrogen peroxide T=5 - 25°C; 6 h;
参考文献
Castellin, Andrea; Stabile, Paolo; Fontana, Francesco; Lucchi, Ottorino De; Caporale, Andrea; Tartaggia, Stefano
Patent: US2012/232281 A1, 2012 ;
Location in patent: Page/Page column 7 ;
反应条件
potassium phosphate; palladium (II) 2,4-pentanedionate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in 1-methyl-pyrrolidin-2-one T=100°C; 18 h; Inert atmosphere; Product distribution / selectivity;
参考文献
Castellin, Andrea; Stabile, Paolo; Fontana, Francesco; Lucchi, Ottorino De; Caporale, Andrea; Tartaggia, Stefano
Patent: US2012/232281 A1, 2012 ;
Location in patent: Page/Page column 7-8 ;
反应条件
1,1-dimethylethylmagnesium chloride in tetrahydrofuran T=65 - 70°C; 1.5 h;
参考文献
F.I.S.- Fabbrica Italiana Sintetici S.p.A.; Brasola, Elena; Fontana, Francesco; Stabile, Paolo; Galvagni, Marco
Patent: EP2551265 A1, 2013 ;
Location in patent: Paragraph 0052-0061 ;
反应条件
1,1-dimethylethylmagnesium chloride in tetrahydrofuran T=50°C;
参考文献
Davies; Marcoux; Corley; Journet; Cai; Palucki; Wu; Larsen; Rossen; Pye; DiMichele; Dormer; Reider
Journal of Organic Chemistry, 2000 , vol. 65, # 25 p. 8415 - 8420
反应条件
1: (4-methylsulfonylphenyl)acetate sodium With 1,1-dimethylethylmagnesium chloride in tetrahydrofuran T=65 - 70°C; 2: methyl 2-methyl-5-pyridinecarboxylate in tetrahydrofuran T=65 - 70°C;
参考文献
EP2551265 A1, ;
Paragraph 0067-0089 ;
反应条件
1: 4-(methylsulfonyl)-phenylacetic acid With sodium hydride in tetrahydrofuran; mineral oil T=45 - 70°C; 1 h; 2: methyl 2-methyl-5-pyridinecarboxylate With 1,1-dimethylethylmagnesium chloride in tetrahydrofuran; mineral oil T=65 - 70°C;
参考文献
EP2551265 A1, ;
Paragraph 0090-0099 ;
反应条件
bis(acetylacetonato) palladium; potassium phosphate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene in dimethyl sulfoxide T=150°C; 16 h; Inert atmosphere;
参考文献
Tartaggia, Stefano; Caporale, Andrea; Fontana, Francesco; Stabile, Paolo; Castellin, Andrea; De Lucchi, Ottorino
RSC Advances, 2013 , vol. 3, # 40 p. 18544 - 18549
反应条件
1: i-PrMgCl / toluene; tetrahydrofuran / 0.5 h / -10 °C 2: 80 percent / tetrahydrofuran; toluene / 1 h / -10 °C 3: 89 percent / sodium tungstate; aq. H2O2 / aq. H2SO4; methanol / 55 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 65, # 25 p. 8415 - 8420
反应条件
1.1: piperidine; tris(4-methylphenyl)-phosphine / palladium diacetate / toluene; 1-methyl-pyrrolidin-2-one / Inert atmosphere 1.2: 40 °C 1.3: 2 h / Reflux 2.1: sulfuric acid / toluene / 50 °C 3.1: potassium phosphate / palladium (II) 2,4-pentanedionate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene / 1-methyl-pyrrolidin-2-one / 18 h / 100 °C / Inert atmosphere View Scheme
反应条件
1.1: pyridine / dichloromethane / 1.5 h / 0 °C 2.1: piperidine; tris(4-methylphenyl)-phosphine / palladium diacetate / toluene; 1-methyl-pyrrolidin-2-one / Inert atmosphere 2.2: 40 °C 2.3: 2 h / Reflux 3.1: sulfuric acid / toluene / 50 °C 4.1: potassium phosphate / palladium (II) 2,4-pentanedionate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene / 1-methyl-pyrrolidin-2-one / 18 h / 100 °C / Inert atmosphere View Scheme
