2-(4-甲磺酰基苯基)-1-(6-甲基吡啶-3-基)-乙酮合成路线 （共 25 条）
反应条件
1: sulfuric acid / toluene / 50 °C 2: potassium phosphate / palladium diacetate; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene / 1-methyl-pyrrolidin-2-one / 18 h / 100 °C / Inert atmosphere View Scheme
反应条件
1: 80 percent / tetrahydrofuran; toluene / 1 h / -10 °C 2: 89 percent / sodium tungstate; aq. H2O2 / aq. H2SO4; methanol / 55 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 65, # 25 p. 8415 - 8420
反应条件
1: 46.5 g / isopropyl acetate / 60 °C 2: 46.5 g / isopropyl acetate / 60 - 65 °C 3: t-BuOK / propan-2-ol; tetrahydrofuran / 0.5 h / 25 °C 4: 24.91 g / aq. HCl / 25 - 45 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 65, # 25 p. 8415 - 8420
反应条件
1: t-BuOK / propan-2-ol; tetrahydrofuran / 0.5 h / 25 °C 2: 24.91 g / aq. HCl / 25 - 45 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 65, # 25 p. 8415 - 8420
反应条件
1.1: toluene / 0.67 h / Reflux 1.2: Reflux 2.1: hydrogenchloride; water; acetic acid / 40 °C / Reflux 2.2: 0.17 h / 0 - 5 °C / pH 7 - 7.2 3.1: sulfuric acid / dichloromethane; water 3.2: 18 - 20 °C 3.3: 0.67 h / 25 - 30 °C / pH 6.95 - 7.1 View Scheme
参考文献
WO2012/66570 A2, ;
WO 2012/066570 A2
反应条件
1: sodium hydroxide / toluene / 2 h / |Inert atmosphere; |Reflux 2: sulfuric acid / toluene / 3 h / 80 °C / |Inert atmosphere 3: bis(acetylacetonato) palladium; 9,9-dimethyl-4,5-bis(diphenyl-phosphino)xanthene; potassium phosphate / 1-methyl-pyrrolidin-2-one / 16 h / 100 °C / |Inert atmosphere View Scheme
参考文献
RSC Advances, , vol. 3, # 40 p. 18544 - 18549
反应条件
1: hydrogenchloride / toluene; water; acetic acid / 20 °C / pH 6.9-7.1 2: sulfuric acid; sodium tungstate; Aliquatreg; 336; dihydrogen peroxide / dichloromethane; water / 18 - 20 °C / pH 6.95-7.10 View Scheme
反应条件
1: lithium hydroxide hydrate / methanol / 1 h / 35 - 40 °C 2: 1,1-dimethylethylmagnesium chloride / tetrahydrofuran / 1.5 h / 65 - 70 °C View Scheme
反应条件
1.1: t-BuOK / tetrahydrofuran / 0.75 h / 20 °C 1.2: 85 percent / AcOH; TFA; NH2OH*HCl / tetrahydrofuran; H2O / 5 h / Heating 2.1: 89 percent / mCPBA View Scheme
参考文献
Davies, Ian W.; Marcoux, Jean-Francois; Reider, Paul J.
Organic Letters, 2001 , vol. 3, # 2 p. 209 - 211
反应条件
1: 1-(6-methylpyridin-3-yl)-2-[(4-methylsulfonyl)-phenyl]-ethanone With potassium tert-butylate in tetrahydrofuran T=10 - 15°C; 1 h; 2: 2-chloro-1,3-(bis-pyrrolidinyl)trimethinium hexafluorophosphate in tetrahydrofuran T=25 - 30°C; 2 h;
参考文献
CADILA HEALTHCARE LIMITED; PANDEY, Bipin; DAVE, Mayank, Ghanshyambhai; SHAH, Mitesh
Patent: WO2010/97802 A2, 2010 ;
Location in patent: Page/Page column 15 ;
