2-(4-甲磺酰基苯基)-1-(6-甲基吡啶-3-基)-乙酮合成路线 （共 25 条）
反应条件
1: With methanesulfonic acid; propionic acid in toluene T=100 - 110°C; 15 h; 2: With sodium hydrogencarbonate in water; ethyl acetate; toluene pH=7 - 7.5;
参考文献
ACTAVIS GROUP PTC EHF; KHUNT, Mayur, Devjibhai; SUBBARAO, Athukuri, Venkata; PRADHAN, Nitin, Sharadchandra; VARMA, Shrikant, Murlidhar
Patent: WO2012/4677 A1, 2012 ;
Location in patent: Page/Page column 22 ;
反应条件
methanesulfonic acid; ammonium acetate; propionic acid in toluene T=25 - 75°C; 14 - 16 h; Reflux;
参考文献
MYLAN LABORATORIES LTD.; DORASALA, Siva Prasad Reddy; NALLA, Raja Mahender Reddy; KOILKONDA, Purandhar; RAMA, Shankar; TUMMANEPALLY, Jagan Mohana Chary
Patent: WO2013/144977 A2, 2013 ;
Location in patent: Page/Page column 7 ;
反应条件
ammonium acetate in propionic acid T=125°C;
参考文献
Journal of Organic Chemistry, , vol. 65, # 25 p. 8415 - 8420
反应条件
1: t-BuOK / tetrahydrofuran / 0.75 h / 20 °C 2: AcOH; TFA / tetrahydrofuran / 0.75 h / 25 - 30 °C 3: 8.42 g / aq. NH4OH / tetrahydrofuran / 3 h / Heating View Scheme
参考文献
CADILA HEALTHCARE LIMITED; DWIVEDI, Shriprakash Dhar; PATEL, Vipul Kantibhai; PATEL, Mahesh Shankarbhai; SHAH, Niraj Shyamlal; PRASAD, Ashok; JAIN, Kuldeep Natwarlal
Patent: WO2013/105106 A1, 2013 ;
反应条件
ammonium acetate in propionic acid T=125°C;
参考文献
Journal of Organic Chemistry, , vol. 65, # 25 p. 8415 - 8420
