1: 1-bromocyclohexane With magnesium in tetrahydrofuran Heating; 2: (3,5-dimethoxyphenyl)carbonitrile in tetrahydrofuran Grignard reaction; 3 h; Heating; 3: With hydrogenchloride in tetrahydrofuran Heating;

1: dimethyl zinc With titanium tetrachloride in dichloromethane; toluene 2: cyclohexyl-(3,5-dimethoxy-phenyl)-methanone in dichloromethane; toluene

1.1: TiCl4 / CH2Cl2; toluene 1.2: 70.3 percent / CH2Cl2; toluene 2.1: 61.9 percent / BBr3 / CH2Cl2 / 0 °C View Scheme